Nasser Nicola J, Fenig Shlomit, Ravid Amiram, Nouriel Ariella, Ozery Naama, Gardyn Sara, Koren Ruth, Fenig Eyal
Institute of Oncology, Davidoff Center, Rabin Medical Center, Beilinson Hospital, Petah Tikva, Israel.
Department of Oncology, Wolfson Hospital, Holon, Israel.
NPJ Breast Cancer. 2017 Mar 31;3:10. doi: 10.1038/s41523-017-0006-x. eCollection 2017.
Radiation dermatitis occurs frequently during adjuvant radiation therapy for breast cancer. Prevention of radiation dermatitis by applying various creams and ointments has a limited success, and Aqua cream which has urea as one of its active ingredients is used in many institutions as a preventive treatment. The primary goal of this study is to assess the effect of vitamin D (calcipotriol) ointment in prevention of radiodermatitis in breast cancer patients compared to Aqua cream. Twenty-three women with localized breast cancer who underwent breast-conserving surgery and opted to receive adjuvant radiotherapy to breast only were enrolled in this study. A cream containing an active vitamin D analog, calcipotriol (Daivonex), was randomly applied either to the medial or to the lateral half of the irradiated breast, while Aqua cream was applied to the complimentary half of the same breast along the whole treatment days, each day, after the delivery of radiation. Skin reaction was recorded and compared between the two halves of the breast. Vitamin D was well tolerated by patients with no local or systemic allergic reactions. Radiation dermatitis was not significantly different between both treatment arms. Topical vitamin D ointment is not superior to Aqua cream for prevention of radiation-induced dermatitis in women treated with adjuvant radiation for breast cancer.
放射性皮炎在乳腺癌辅助放疗期间经常发生。通过涂抹各种乳膏和软膏来预防放射性皮炎的效果有限，许多机构将含有尿素作为活性成分之一的水乳膏用作预防性治疗。本研究的主要目的是评估与水乳膏相比，维生素D（卡泊三醇）软膏对乳腺癌患者放射性皮炎的预防效果。本研究纳入了23例接受保乳手术且选择仅对乳房进行辅助放疗的局限性乳腺癌女性患者。一种含有活性维生素D类似物卡泊三醇（达力士）的乳膏被随机涂抹于照射乳房的内侧或外侧一半，而水乳膏则在整个治疗期间每天放疗后涂抹于同一乳房的另一半。记录并比较乳房两半的皮肤反应。患者对维生素D耐受性良好，未出现局部或全身过敏反应。两个治疗组之间的放射性皮炎无显著差异。对于接受乳腺癌辅助放疗的女性，局部使用维生素D软膏在预防放射性皮炎方面并不优于水乳膏。
