Kodirov Sodikdjon A
I. P. Pavlov Department of Physiology, State Research Institute of Experimental Medicine, Russian Academy of Medical Sciences, Saint Petersburg 197376, Russia.
University of Texas at Brownsville, Department of Biological Sciences, Texas 78520, USA.
Ther Targets Neurol Dis. 2017;4. Epub 2017 Jan 30.
Since the reward center is considered to be the of the hypothalamus, logically its neurons could mainly be responsible for addiction. However, the literature asserts that almost any neurons of CNS can respond to one or another addictive compound. Obviously not only addictive nicotine, but also alcohol, amphetamine, cannabis, cocaine, heroin and morphine may influence dopaminergic cells alone in VTA. Moreover, paradoxically some of these drugs ameliorate symptoms, counterbalance syndromes, cure diseases and improve health, not only those related to the CNS and in adults, but also almost all other organs and in children, e.g. epilepsy.
由于奖赏中枢被认为位于下丘脑，从逻辑上讲，其神经元可能主要负责成瘾。然而，文献表明中枢神经系统的几乎任何神经元都能对一种或另一种成瘾性化合物作出反应。显然，不仅成瘾性的尼古丁，而且酒精、安非他命、大麻、可卡因、海洛因和吗啡都可能单独影响中脑腹侧被盖区的多巴胺能细胞。此外，矛盾的是，这些药物中的一些不仅能改善与中枢神经系统相关的症状、平衡综合征、治愈疾病并改善健康状况，不仅在成年人中如此，在儿童中对几乎所有其他器官也有这样的作用，例如癫痫。
