a Department of Periodontology (CHU/Rmes Inserm U1229/UIC11), Faculty of Dental Surgery , University of Nantes , Nantes , France.
b Division of Biomedical Sciences, Faculty of Dentistry , McGill University , Montreal , QC , Canada.
Platelets. 2018 Mar;29(2):105-112. doi: 10.1080/09537104.2017.1327656. Epub 2017 Jun 26.
Activated platelet concentrates are autologous blood preparations containing supraphysiological concentration of platelets. Platelet concentrates are commonly used for bone regeneration purposes based on the fact that growth factors released from activated platelets alpha granules have osteoinductive effects on bone cells. Although most preclinical and clinical studies show that platelet concentrates improve the outcomes of bone regeneration procedures, some studies reported conflicting results and even negative effects on bone healing. Several confounding parameters have been suggested as possible reasons for such inconsistencies (i.e. preparation and activation methods). However, heterogeneity in clinical studies makes drawing evidence-based conclusions difficult. On the other hand, recent findings show that the constituents of platelets dense granules (i.e. serotonin, ATP, Ca) have potential inhibitory effects on bone metabolism. Accordingly, we suggest that a partial explanation for the conflicting results could be the potential negative effects that dense granules may have on bone healing.
活化血小板浓缩物是含有超生理浓度血小板的自体血液制剂。血小板浓缩物通常用于骨再生目的，这是基于从活化血小板α颗粒释放的生长因子对骨细胞具有成骨诱导作用的事实。尽管大多数临床前和临床研究表明血小板浓缩物可改善骨再生程序的结果，但一些研究报告了相互矛盾的结果，甚至对骨愈合有负面影响。已经提出了几个混杂参数作为这种不一致的可能原因（即制备和激活方法）。然而，临床研究的异质性使得难以得出基于证据的结论。另一方面，最近的发现表明血小板致密颗粒的成分（即 5-羟色胺、ATP、Ca）对骨代谢可能具有潜在的抑制作用。因此，我们建议，对矛盾结果的部分解释可能是致密颗粒对骨愈合可能产生的潜在负面影响。
