Ali Zubair, Daniyal Muhammad, Adhia Muhammad Khalid, Alam Anees, Sarfaraz Babar, Sattar Abdul, Usmanghani Khan
Department of Medical Affairs and Training, Herbion Pharmaceutical (Pvt.) Limited Karachi Pakistan.
Hamdard University Hospital, Taj Medical Complex M. A Jinnah Road, Karachi Pakistan.
Pak J Pharm Sci. 2017 Mar;30(2(Suppl.)):591-596.
The cough and cold are very widespread conditions and a common purpose for advice in general practice. Utmost often the sign and symptoms of cough are produced by acute viral airway infection and the course is frequently benign. But it can be converted into bacterial super-infection and can cause acute bronchitis. Herbal medicines are used to treat symptoms of the cough and cold, and among these medicines Ivy leaf is used to treat mucous discharge and irritation in throat due to the cough and cold. In addition to synthetic substances such as acetylcysteine, carbocisteins, ambroxol and bromhexine, herbal medicines contain saponins, which are used in these indications. Not just Ivy, but also the marshmallow and mustard seeds used for these indications. This clinical trial was conducted in 220 patients, in which 110 receive the CofNovex plus European Medicines Agency (EMA) syrup and 110 receive the placebo. The age range of patients was 3 years to above 15 years. The sample paired t-test was applied to evaluate the significant level. CofNovex plus (EMA) syrup was very effective in treating cough and cold symptoms. The new treatment CofNovex plus (EMA) syrup was safe and well tolerated in patient at given specific age group.
咳嗽和感冒极为常见，是全科医疗中寻求建议的常见原因。咳嗽的体征和症状通常由急性病毒性气道感染引起，病程往往呈良性。但它可能会转变为细菌重叠感染并引发急性支气管炎。草药用于治疗咳嗽和感冒症状，其中常春藤叶用于治疗因咳嗽和感冒引起的黏液分泌及喉咙不适。除了乙酰半胱氨酸、羧甲司坦、氨溴索和溴己新等合成物质外，草药还含有皂苷，这些物质用于这些适应症。不仅常春藤，用于这些适应症的还有药蜀葵和芥菜籽。这项临床试验针对220名患者进行，其中110名接受CofNovex加欧洲药品管理局（EMA）糖浆治疗，110名接受安慰剂治疗。患者年龄范围为3岁至15岁以上。采用样本配对t检验来评估显著水平。CofNovex加（EMA）糖浆在治疗咳嗽和感冒症状方面非常有效。在特定年龄组的患者中，新的治疗方法CofNovex加（EMA）糖浆安全且耐受性良好。
