Bharti Vandana, Mehta Archana, Mourya Gajendra Kumar, Ahirwal Laxmi, Bajpai Vivek K, Shukla Shruti
Department of Botany, Lab of Molecular Biology, Dr. Hari Singh Gour University (Central University), Sagar, MP, India.
Department of Biomedical Engineering, School of Technology, North Eastern Hill University, Shillong, Meghalaya, India.
Pak J Pharm Sci. 2017 Mar;30(2(Suppl.)):597-600.
This research was aimed to investigate anti-hyperglycemic effects of two Lactobacillus spp. on alloxan induced diabetic rats. Alloxan was administered intraperitoneally to induce the diabetic conditions in experimental rats. Animals were treated with oral administration of Lactobacillus spp., such as L. plantarum and L. acidophilus at the dose of 10 CFU/ml. As a result, administration of Lactobacillus spp. significantly (P<0.05) lowered blood glucose levels in diabetic rats by (201-220mg/dl) as compared to diabetic control (265mg/dl). Also, both the Lactobacillus spp. were able to reduce body weight of experimental animals as compared to control group, suggesting potent anti-hyperglycemic effect of Lactobacillus spp. in terms of their anti-diabetic potential.
本研究旨在探讨两种乳酸杆菌对四氧嘧啶诱导的糖尿病大鼠的降血糖作用。通过腹腔注射四氧嘧啶诱导实验大鼠患糖尿病。动物经口给予乳酸杆菌，如植物乳杆菌和嗜酸乳杆菌，剂量为10CFU/ml。结果，与糖尿病对照组（265mg/dl）相比，给予乳酸杆菌能显著（P<0.05）降低糖尿病大鼠的血糖水平（降至201 - 220mg/dl）。此外，与对照组相比，两种乳酸杆菌均能降低实验动物的体重，提示乳酸杆菌就其抗糖尿病潜力而言具有强大的降血糖作用。
