Shibata S, Ueda S, Satake N
Comp Biochem Physiol C Comp Pharmacol Toxicol. 1985;82(1):129-36.
Pretreatment with acebutolol or propranolol at high concentrations had an inhibitory effect on the contractile response to 5-hydroxytryptamine (5-HT) in most vascular smooth muscles such as rabbit aorta and basilar, mesenteric, renal, femoral arteries and cat coronary artery. The inhibitory actions of both agents were generally greater than on the responses to excess Ca2+ and potassium. In rabbit renal arteries, acebutolol had no effect on the response to 5-HT but inhibited the responses to excess Ca2+ and potassium. Propranolol had a marked inhibitory effect on the response to 5-HT. In all preparations used, the contractions induced by norepinephrine (NE) and histamine showed a much greater resistance to the effect of acebutolol and propranolol than the contractions induced by 5-HT, Ca2+ and potassium. Nifedipine had no inhibitory effect on the response to 5-HT in most of the preparations. Nifedipine inhibited the response to 5-HT only in the basilar arteries. The inhibitory actions of propranolol on the response to 5-HT was greater than that of acebutolol. The inhibitory action of acebutolol and propranolol on the response to 5-HT may be related to mechanisms other than the beta-adrenoceptor blocking action of the drugs. The possible mechanisms of inhibitory action of both beta-adrenoceptor antagonists on 5-HT are discussed.
在大多数血管平滑肌（如兔主动脉、基底动脉、肠系膜动脉、肾动脉、股动脉和猫冠状动脉）中，高浓度的醋丁洛尔或普萘洛尔预处理对5-羟色胺（5-HT）引起的收缩反应具有抑制作用。这两种药物的抑制作用通常比对过量Ca2+和钾的反应更强。在兔肾动脉中，醋丁洛尔对5-HT的反应无影响，但抑制对过量Ca2+和钾的反应。普萘洛尔对5-HT的反应有明显抑制作用。在所有使用的标本中，去甲肾上腺素（NE）和组胺诱导的收缩比5-HT、Ca2+和钾诱导的收缩对醋丁洛尔和普萘洛尔的作用表现出更大的耐受性。硝苯地平在大多数标本中对5-HT的反应无抑制作用。硝苯地平仅在基底动脉中抑制对5-HT的反应。普萘洛尔对5-HT反应的抑制作用大于醋丁洛尔。醋丁洛尔和普萘洛尔对5-HT反应的抑制作用可能与药物的β-肾上腺素能受体阻断作用以外的机制有关。讨论了两种β-肾上腺素能拮抗剂对5-HT抑制作用的可能机制。
