Al-Daghri Nasser M, Mohammed Abdul Khader, Al-Attas Omar S, Draz Hossam M, Alokail Majed S
1 Prince Mutaib Chair for Biomarkers of Osteoporosis, Department of Biochemistry, College of Science, King Saud University , Riyadh, Kingdom of Saudi Arabia.
2 Biomarker Research Program, Department of Biochemistry, College of Science, King Saud University , Riyadh, Kingdom of Saudi Arabia.
Genet Test Mol Biomarkers. 2017 Jul;21(7):422-427. doi: 10.1089/gtmb.2016.0320. Epub 2017 Jun 26.
Variations in fibroblast growth factor (FGF) levels have been associated with alterations in blood pressure. FGFs mediate their function through binding to their FGF receptor (FGFR). The FGFR4 Gly388Arg polymorphism is associated with cancer and cardiovascular diseases, but its association with hypertension is unclear. Here, we aimed to investigate the association between the FGFR4 Gly388Arg polymorphism and hypertension.
Three hundred Saudi individuals (150 normotensive controls and 150 hypertensive subjects) were genotyped for the FGFR4 Gly388Arg (G/A) polymorphism using polymerase chain reaction-restriction fragment length polymorphism method. Anthropometrics, glucose and lipid profiles were measured for all subjects. The frequency of the FGFR4 Arg388 (A) allele was significantly higher in hypertensive subjects (36%) than controls (24.3%) (odds ratio [OR] 2.4, 95% confidence interval [CI] 1.5-3.83, p < 0.001). In addition, GA (OR 2.51, 95% CI 1.3-4.85, p = 0.006), AA (OR 5.58, 95% CI 1.79-11.8, p = 0.003), and GA + AA (OR 2.91, 95% CI 1.55-5.46, p = 0.001) genotypes were significantly associated with the risk of hypertension, even after adjusting for age, body mass index, and glucose. Gender stratification showed a significant association only in female subjects (p < 0.001). Furthermore, subjects with GA and AA genotypes showed significantly higher diastolic blood pressure than those with GG genotype (p = 0.004).
The FGFR4 Arg388 allele is associated with an increased risk of hypertension in Saudi female subjects. The lack of association in men needs to be further investigated.
成纤维细胞生长因子（FGF）水平的变化与血压改变有关。FGFs通过与其FGF受体（FGFR）结合来介导其功能。FGFR4 Gly388Arg多态性与癌症和心血管疾病有关，但其与高血压的关联尚不清楚。在此，我们旨在研究FGFR4 Gly388Arg多态性与高血压之间的关联。
采用聚合酶链反应-限制性片段长度多态性方法对300名沙特人（150名血压正常对照者和150名高血压患者）进行FGFR4 Gly388Arg（G/A）多态性基因分型。测量所有受试者的人体测量指标、血糖和血脂水平。高血压患者中FGFR4 Arg388（A）等位基因的频率（36%）显著高于对照组（24.3%）（优势比[OR] 2.4，95%置信区间[CI] 1.5 - 3.83，p < 0.001）。此外，即使在调整年龄、体重指数和血糖后，GA（OR 2.51，95% CI 1.3 - 4.85，p = 0.006）、AA（OR 5.58，95% CI 1.79 - 11.8，p = 0.003）以及GA + AA（OR 2.91，95% CI 1.55 - 5.46）基因型仍与高血压风险显著相关。性别分层显示仅在女性受试者中存在显著关联（p < 0.001）。此外，携带GA和AA基因型的受试者舒张压显著高于携带GG基因型的受试者（p = 0.004）。
FGFR4 Arg388等位基因与沙特女性受试者患高血压风险增加有关。男性中缺乏关联这一情况有待进一步研究。
