醋丁洛尔在正常血压和自发性高血压大鼠中的急性血流动力学效应及组织分布

Acute haemodynamic effects and tissue distribution of acebutolol in normotensive and spontaneously hypertensive rats.

作者信息

Midol-Monnet M, Heimburger M, Davy M, Beslot F, Wepierre J, Cohen Y, Barre J

出版信息

Comp Biochem Physiol C Comp Pharmacol Toxicol. 1985;82(1):75-9. doi: 10.1016/0742-8413(85)90212-9.

Abstract

Acute i.v. administration of 15 mg/kg acebutolol in normotensive (WKY), Okamoto (SHR) and Okamoto stroke-prone (SHR-SP) awake rats resulted in weak effects on blood pressure and in bradycardia more marked in SHR-SP. Thirty minutes after i.v. administration, lung and renal uptake of [14C]acebutolol was reduced in SHR compared to other rats. Muscle uptake was higher in SHR and blood concentration was higher in SHR-SP. Brain levels were low and similar in all rats. Plasma protein binding was identical in all rats. These results are discussed according to the characteristics of the three strains studied.

摘要

对正常血压的清醒大鼠（WKY）、冈本高血压大鼠（SHR）和冈本易卒中型高血压大鼠（SHR-SP）静脉注射15mg/kg醋丁洛尔，结果显示其对血压的影响较弱，且心动过缓在SHR-SP中更为明显。静脉注射后30分钟，与其他大鼠相比，SHR中[14C]醋丁洛尔的肺和肾摄取减少。SHR的肌肉摄取较高，SHR-SP的血药浓度较高。所有大鼠的脑内浓度较低且相似。所有大鼠的血浆蛋白结合率相同。根据所研究的三种品系的特征对这些结果进行了讨论。