Midol-Monnet M, Heimburger M, Davy M, Beslot F, Cohen Y
Comp Biochem Physiol C Comp Pharmacol Toxicol. 1987;87(1):83-6. doi: 10.1016/0742-8413(87)90186-1.
Tissue distribution of acebutolol was studied in 33-week-old normotensive (WKY) and Okamoto stroke-prone (SHR-SP) rats, 30 min after an i.v. administration, by using 14C-acebutolol. Plasma level of acebutolol was higher in WKY than in SHR-SP. Aorta, kidney, liver and muscle radioactivity/plasma radioactivity ratios were higher in SHR-SP than in WKY. The brain/plasma radioactivity ratio was very low and similar in the two groups. The drug distribution was the same in the two groups except in medulla + corpus trapezoides where drug concentration was greater in SHR-SP. These results, compared with previous ones, show an age-related evolution in pathological state in SHR-SP. They point out a specific concentration of the beta-blocking drug in a defined part of the brain, namely medulla + corpus trapezoides.
通过静脉注射14C-醋丁洛尔后30分钟，在33周龄的正常血压大鼠（WKY）和冈本易卒中大鼠（SHR-SP）中研究了醋丁洛尔的组织分布。WKY大鼠的醋丁洛尔血浆水平高于SHR-SP大鼠。SHR-SP大鼠的主动脉、肾脏、肝脏和肌肉放射性/血浆放射性比值高于WKY大鼠。两组的脑/血浆放射性比值非常低且相似。除了延髓+梯形体，两组的药物分布相同，在延髓+梯形体中SHR-SP大鼠的药物浓度更高。与之前的结果相比，这些结果显示了SHR-SP大鼠病理状态下与年龄相关的演变。它们指出了β受体阻滞剂在大脑特定部位，即延髓+梯形体中的特定浓度。
