Ocak Hakan, Kutuk Nukhet, Demetoglu Umut, Balcıoglu Esra, Ozdamar Saim, Alkan Alper
1 Department of Oral and Maxillofacial Surgery, Faculty of Dentistry, Erciyes University, Kayseri, Turkey.
2 Department of Oral and Maxillofacial Surgery, Faculty of Dentistry, Adnan Menderes University, Aydın, Turkey.
J Oral Implantol. 2017 Jun;43(3):194-201. doi: 10.1563/aaid-joi-D-16-00104. Epub 2017 Mar 13.
Numerous grafting materials have been used to augment the maxillary sinus floor for long-term stability and success for implant-supported prosthesis. To enhance bone formation, adjunctive blood-born growth factor sources have gained popularity during the recent years. The present study compared the use of platelet-rich fibrin (PRF) and bovine-autogenous bone mixture for maxillary sinus floor elevation. A split-face model was used to apply 2 different filling materials for maxillary sinus floor elevation in 22 healthy adult sheep. In group 1, bovine and autogenous bone mixture; and in group 2, PRF was used. The animals were killed at 3, 6, and 9 months. Histologic and histomorphologic examinations revealed new bone formation in group 1 at the third and sixth months. In group 2, new bone formation was observed only at the sixth month, and residual PRF remnants were identified. At the ninth month, host bone and new bone could not be distinguished from each other in group 1, and bone formation was found to be proceeding in group 2. PRF remnants still existed at the ninth month. In conclusion, bovine bone and autogenous bone mixture is superior to PRF as a grafting material in sinus-lifting procedures.
为了实现种植体支持的修复体的长期稳定性和成功，已经使用了多种移植材料来增加上颌窦底。为了促进骨形成，近年来，辅助性血源性生长因子来源受到了广泛关注。本研究比较了富血小板纤维蛋白（PRF）和牛自体骨混合物在上颌窦底提升中的应用。采用裂脸模型，对22只健康成年绵羊的上颌窦底提升应用两种不同的填充材料。第1组使用牛骨和自体骨混合物；第2组使用PRF。在3、6和9个月时处死动物。组织学和组织形态学检查显示，第1组在第3个月和第6个月有新骨形成。在第2组中，仅在第6个月观察到新骨形成，并发现有残留的PRF。在第9个月时，第1组中宿主骨和新骨无法区分，第2组中骨形成仍在进行。第9个月时PRF残留仍然存在。总之，在窦底提升手术中，牛骨和自体骨混合物作为移植材料优于PRF。
