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一名患有X连锁慢性肉芽肿病的4岁男孩因贝塞斯达颗粒杆菌感染导致暴发性脓毒症

Fulminant Sepsis Due to Granulibacter bethesdensis in a 4-Year-Old Boy With X-Linked Chronic Granulomatous Disease.

作者信息

Mayer Erick F, Gialanella Philip, Munjal Iona, Cunningham-Rundles Charlotte, Dara Jasmeen

机构信息

From the *Department of Pediatrics, Children's Hospital at Montefiore and Albert Einstein College of Medicine, Bronx, †Department of Microbiology and Pathology, Montefiore Medical Center and Albert Einstein College of Medicine, Bronx, and ‡Department of Medicine, Mount Sinai Hospital and Icahn School of Medicine, New York, New York.

出版信息

Pediatr Infect Dis J. 2017 Dec;36(12):1165-1166. doi: 10.1097/INF.0000000000001659.

DOI:10.1097/INF.0000000000001659
PMID:28650935
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5897898/
Abstract

Granulibacter bethesdensis is a Gram-negative bacillus described as a pathogen exclusively in patients with chronic granulomatous disease, a phagocytic disorder that impairs the ability to clear catalase-producing organisms. Granulibacter usually causes chronic and recurrent lymphadenopathies. We report the fatal case of a 4-year-old boy with chronic granulomatous disease, who presented with sepsis after a few days of abdominal pain and diarrhea.

摘要

贝塞斯达颗粒杆菌是一种革兰氏阴性杆菌,据描述它仅在患有慢性肉芽肿病的患者中作为病原体出现,慢性肉芽肿病是一种吞噬功能障碍性疾病,会损害清除产过氧化氢酶生物体的能力。颗粒杆菌通常会导致慢性复发性淋巴结病。我们报告了一例4岁慢性肉芽肿病男孩的致命病例,该男孩在出现腹痛和腹泻几天后发生了败血症。

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本文引用的文献

1
Early Intracellular Trafficking of Granulibacter bethesdensis in Human Macrophages.嗜贝氏颗粒杆菌在人巨噬细胞中的早期细胞内运输
Infect Immun. 2017 May 23;85(6). doi: 10.1128/IAI.00847-16. Print 2017 Jun.
2
Methylotroph Infections and Chronic Granulomatous Disease.甲基营养菌感染与慢性肉芽肿病
Emerg Infect Dis. 2016 Mar;22(3):404-9. doi: 10.3201/eid2203.151265.
3
Serologic reactivity to the emerging pathogen Granulibacter bethesdensis.对新兴病原体贝氏疏螺旋体的血清学反应性。
J Infect Dis. 2012 Sep 15;206(6):943-51. doi: 10.1093/infdis/jis431. Epub 2012 Jul 10.
4
Innate immunity against Granulibacter bethesdensis, an emerging gram-negative bacterial pathogen.先天免疫对抗 Granulibacter bethesdensis,一种新兴的革兰氏阴性细菌病原体。
Infect Immun. 2012 Mar;80(3):975-81. doi: 10.1128/IAI.05557-11. Epub 2011 Dec 19.
5
Recurrent Granulibacter bethesdensis infections and chronic granulomatous disease.反复发生的贝氏疏螺旋体感染和慢性肉芽肿病。
Emerg Infect Dis. 2010 Sep;16(9):1341-8. doi: 10.3201/eid1609.091800.
6
Granulibacter bethesdensis isolated in a child patient with chronic granulomatous disease.从一名患有慢性肉芽肿病的儿童患者中分离出贝塞斯达颗粒杆菌。
J Infect. 2008 Sep;57(3):275-7. doi: 10.1016/j.jinf.2008.04.011. Epub 2008 Jun 16.
7
A novel bacterium associated with lymphadenitis in a patient with chronic granulomatous disease.一名慢性肉芽肿病患者中与淋巴结炎相关的新型细菌。
PLoS Pathog. 2006 Apr;2(4):e28. doi: 10.1371/journal.ppat.0020028. Epub 2006 Apr 14.