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X 连锁慢性肉芽肿病患者感染毒力较强的贝氏疏螺旋体导致的致命性脑膜炎。

Fatal Meningitis in Patient with X-Linked Chronic Granulomatous Disease Caused by Virulent Granulibacter bethesdensis.

出版信息

Emerg Infect Dis. 2019 May;25(5):976-979. doi: 10.3201/eid2505.181505.

DOI:10.3201/eid2505.181505
PMID:31002074
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6478198/
Abstract

Granulibacter bethesdensis is a pathogen reported to cause recurrent lymphadenitis exclusively in persons with chronic granulomatous disease. We report a case of fatal meningitis caused by a highly virulent G. bethesdensis strain in an adolescent in Europe who had chronic granulomatous disease.

摘要

贝氏疏螺旋体是一种病原体,据报道仅在患有慢性肉芽肿病的人群中引起复发性淋巴结炎。我们报告了一例在欧洲患有慢性肉芽肿病的青少年中由高毒力贝氏疏螺旋体菌株引起的致命性脑膜炎病例。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b097/6478198/0660fb7f59ff/18-1505-F2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b097/6478198/068f3b9a04a2/18-1505-F1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b097/6478198/0660fb7f59ff/18-1505-F2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b097/6478198/068f3b9a04a2/18-1505-F1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b097/6478198/0660fb7f59ff/18-1505-F2.jpg

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本文引用的文献

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Recent advances in understanding and treating chronic granulomatous disease.慢性肉芽肿病的认识与治疗新进展
F1000Res. 2017 Aug 11;6:1427. doi: 10.12688/f1000research.11789.1. eCollection 2017.
2
Fulminant Sepsis Due to Granulibacter bethesdensis in a 4-Year-Old Boy With X-Linked Chronic Granulomatous Disease.一名患有X连锁慢性肉芽肿病的4岁男孩因贝塞斯达颗粒杆菌感染导致暴发性脓毒症
Pediatr Infect Dis J. 2017 Dec;36(12):1165-1166. doi: 10.1097/INF.0000000000001659.
3
Methylotroph Infections and Chronic Granulomatous Disease.甲基营养菌感染与慢性肉芽肿病
Emerg Infect Dis. 2016 Mar;22(3):404-9. doi: 10.3201/eid2203.151265.
4
Persistence of the bacterial pathogen Granulibacter bethesdensis in chronic granulomatous disease monocytes and macrophages lacking a functional NADPH oxidase.格兰氏阴性分枝杆菌在缺乏功能性 NADPH 氧化酶的慢性肉芽肿病的单核细胞和巨噬细胞中持续存在。
J Immunol. 2013 Sep 15;191(6):3297-307. doi: 10.4049/jimmunol.1300200. Epub 2013 Aug 16.
5
Chronic granulomatous disease.慢性肉芽肿病。
Hematol Oncol Clin North Am. 2013 Feb;27(1):89-99, viii. doi: 10.1016/j.hoc.2012.11.002. Epub 2012 Nov 22.
6
Innate immunity against Granulibacter bethesdensis, an emerging gram-negative bacterial pathogen.先天免疫对抗 Granulibacter bethesdensis,一种新兴的革兰氏阴性细菌病原体。
Infect Immun. 2012 Mar;80(3):975-81. doi: 10.1128/IAI.05557-11. Epub 2011 Dec 19.
7
Recurrent Granulibacter bethesdensis infections and chronic granulomatous disease.反复发生的贝氏疏螺旋体感染和慢性肉芽肿病。
Emerg Infect Dis. 2010 Sep;16(9):1341-8. doi: 10.3201/eid1609.091800.
8
Granulibacter bethesdensis isolated in a child patient with chronic granulomatous disease.从一名患有慢性肉芽肿病的儿童患者中分离出贝塞斯达颗粒杆菌。
J Infect. 2008 Sep;57(3):275-7. doi: 10.1016/j.jinf.2008.04.011. Epub 2008 Jun 16.
9
Genome sequence analysis of the emerging human pathogenic acetic acid bacterium Granulibacter bethesdensis.新出现的人类病原性醋酸杆菌贝塞斯达颗粒杆菌的基因组序列分析。
J Bacteriol. 2007 Dec;189(23):8727-36. doi: 10.1128/JB.00793-07. Epub 2007 Sep 7.
10
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