Mouse Informatics Group, The Wellcome Trust Sanger Institute, Hinxton, Cambridge CB10 1SA, UK.
Quantitative Biology, AstraZeneca, Unit 310, Cambridge Science Park, Cambridge CB4 0WG, UK.
Nat Commun. 2017 Jun 26;8:15475. doi: 10.1038/ncomms15475.
The role of sex in biomedical studies has often been overlooked, despite evidence of sexually dimorphic effects in some biological studies. Here, we used high-throughput phenotype data from 14,250 wildtype and 40,192 mutant mice (representing 2,186 knockout lines), analysed for up to 234 traits, and found a large proportion of mammalian traits both in wildtype and mutants are influenced by sex. This result has implications for interpreting disease phenotypes in animal models and humans.
性别在生物医学研究中的作用常常被忽视，尽管一些生物学研究已经证实了性别二态效应的存在。在这里，我们使用了来自 14250 只野生型和 40192 只突变型小鼠（代表 2186 条敲除系）的高通量表型数据，分析了多达 234 个特征，我们发现野生型和突变型小鼠的很大一部分哺乳动物特征都受到性别影响。这一结果对解释动物模型和人类中的疾病表型具有重要意义。
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