Qilu Hospital of Shandong University, Qingdao, Shandong, China.
Qilu Hospital of Shandong University, Qingdao, Shandong, China.
Biomed Pharmacother. 2017 Sep;93:344-351. doi: 10.1016/j.biopha.2017.06.059. Epub 2017 Jun 24.
Alpinumisoflavone (AIF), a naturally occurring flavonoid compound exacted from Derris eriocarpa, has been found to have a number of pharmacological activities. However, its role in bone disorder has not been investigated. The aim of this study is to evaluate the osteoprotective effect of AIF on ovariectomy-induced bone loss in mice model and related underlying mechanisms. Our study provides experimental evidence that AIF could regulate the remodeling process of bone and exert osteoprotective effect against ovariectomy-induced bone loss. Moreover, our results show that AIF suppresses osteoclast differentiation by attenuating RANKL-induced activation of p38, ERK and JNK pathways and consequently represses the expression of c-Fos and NFATc1.
阿朴双黄酮（AIF）是从鱼藤中提取的一种天然黄酮类化合物，已被发现具有多种药理活性。然而，其在骨骼疾病中的作用尚未被研究。本研究旨在评估 AIF 对去卵巢小鼠模型骨丢失的护骨作用及其相关的潜在机制。本研究提供了实验证据，表明 AIF 可以调节骨重塑过程，并发挥对去卵巢引起的骨丢失的护骨作用。此外，我们的结果表明，AIF 通过抑制 RANKL 诱导的 p38、ERK 和 JNK 通路的激活来抑制破骨细胞分化，从而抑制 c-Fos 和 NFATc1 的表达。
