Vinogradov Evgeny, St Michael Frank, Cox Andrew D
Vaccine Program, Human Health Therapeutics Portfolio, National Research Council, Ottawa, ON, K1A 0R6, Canada.
Vaccine Program, Human Health Therapeutics Portfolio, National Research Council, Ottawa, ON, K1A 0R6, Canada.
Carbohydr Res. 2017 Aug 7;448:115-117. doi: 10.1016/j.carres.2017.06.007. Epub 2017 Jun 16.
Fusobacterium nucleatum is an anaerobic bacterium found in the human mouth where it causes periodontitis. It was also found in colorectal cancer tissues and is linked with pregnancy complications, including pre-term and still births. Cell surface structures of the bacterium could be implicated in pathogenesis. Here we report the following structure of the lipopolysaccharide O-chain of F. nucleatum strain 12230: -6-α-d-Glc-4-β-d-GlcNHBu3NHBuA-3-β-d-QuiNAc4NABu- where ABu and HBu indicate (R)-3-aminobutanoyl and (R)-3-hydroxybutanoyl, respectively; all monosaccharides are in the pyranose form.
具核梭杆菌是一种存在于人类口腔中可引发牙周炎的厌氧菌。它也在结直肠癌组织中被发现，并且与包括早产和死产在内的妊娠并发症有关。该细菌的细胞表面结构可能与发病机制有关。在此我们报告具核梭杆菌12230菌株脂多糖O链的以下结构：-6-α-d-葡萄糖-4-β-d-葡萄糖胺基丁三胺基丁糖醛酸-3-β-d-奎诺糖胺4-氨基丁糖- 其中ABu和HBu分别表示（R）-3-氨基丁酰基和（R）-3-羟基丁酰基；所有单糖均为吡喃糖形式。
