五株具核梭杆菌（Fusobacterium nucleatum）CTX47T、CC2_6JVN3、CC2_3FMU1、CC2_1JVN3、HM-996 的 LPS O-链结构，其主链中含有糖醇和磷酸盐，并开发出针对 O-抗原的特异性小鼠单克隆抗体。
The structure of the LPS O-chain from five Fusobacterium nucleatum strains CTX47T, CC2_6JVN3, CC2_3FMU1, CC2_1JVN3, HM-996, containing alditol and phosphate in the main chain and development of mouse monoclonal antibodies specific to the O-antigens.
机构信息
Vaccine Program, Human Health Therapeutics Portfolio, National Research Council, Ottawa, ON, K1A 0R6, Canada.
Vaccine Program, Human Health Therapeutics Portfolio, National Research Council, Ottawa, ON, K1A 0R6, Canada.
出版信息
Carbohydr Res. 2022 Nov;521:108648. doi: 10.1016/j.carres.2022.108648. Epub 2022 Aug 12.
Fusobacterium nucleatum is an anaerobic bacterium found in the human mouth where it causes periodontitis. It was also found in colorectal cancer tissues and is linked with pregnancy complications, including pre-term and stillbirths. Cell surface structures of the bacterium could be implicated in pathogenesis. Here we report four new structures of the lipopolysaccharide O-chain (OPS) from five strains of F. nucleatum CTX47T, CC2_6JVN3, CC2_3FMU1, CC2_1JVN3, HM-996, isolated from cancerous tissues. Three of the four structures have a common sequence of hexose-diaminofucose-hexitol-phosphate in the main chain.
具核梭杆菌是一种存在于人类口腔中的厌氧细菌，可引起牙周炎。它也存在于结直肠癌组织中，并与妊娠并发症有关，包括早产和死产。该细菌的细胞表面结构可能与发病机制有关。在这里，我们报告了来自癌症组织的五株具核梭杆菌 CTX47T、CC2_6JVN3、CC2_3FMU1、CC2_1JVN3、HM-996 的脂多糖 O-链 (OPS) 的四个新结构。这四个结构中有三个在主链上具有六糖-二氨基葡萄糖-己糖醇-磷酸的共同序列。
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