一种新的血红蛋白变体，Hb Mito [β144(HC 1) 赖氨酸→谷氨酸]，具有增加的氧亲和力。
A new hemoglobin variant, Hb Mito [beta 144(HC 1) Lys----Glu], with increased oxygen affinity.
作者信息
Harano K, Harano T, Ueda S, Ohkushi T, Imai K
出版信息
FEBS Lett. 1985 Nov 11;192(1):75-8. doi: 10.1016/0014-5793(85)80046-6.
PMID:2865170
Abstract
A new abnormal hemoglobin, Hb Mito [beta 144(HC 1) Lys----Glu], with an amino acid substitution in the 2,3-DPG pocket, was discovered in a Japanese female. This hemoglobin showed increased oxygen affinity, and decreased organic phosphate and Bohr effects, while the Hill constant n was normal.
摘要
在一名日本女性中发现了一种新的异常血红蛋白Hb Mito [β144(HC 1)赖氨酸→谷氨酸]，其2,3 -二磷酸甘油酸（2,3-DPG）结合位点存在氨基酸替换。这种血红蛋白表现出氧亲和力增加、有机磷酸盐效应降低和波尔效应降低，而希尔常数n正常。
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