预防川崎病中的冠状动脉病变。
Preventing coronary artery lesions in Kawasaki disease.
作者信息
Kuo Ho-Chang
机构信息
Kawasaki Disease Center, Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine, Kaohsiung, Taiwan; Department of Pediatrics, Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine, Kaohsiung, Taiwan; College of Medicine, Chang Gung University, Taoyuan, Taiwan.
出版信息
Biomed J. 2017 Jun;40(3):141-146. doi: 10.1016/j.bj.2017.04.002. Epub 2017 May 30.
A form of systemic vasculitis that affects mostly small and medium-sized vessels, Kawasaki disease (KD) is most commonly found in children under the age of 5 years old. Though its etiology is unknown, KD has been the most frequent acquired heart disease in developing countries. Its incidence has increased over recent decades in many centuries, including Japan, Korea, and China. The most severe complications of KD are coronary artery lesions (CAL), including dilation, fistula, aneurysm, arterial remodeling, stenosis, and occlusion. Aneurysm formation has been observed in 20-25% of KD patients that do not receive intravenous immunoglobulin (IVIG) treatment, and in 3-5% that do receive it. Coronary artery dilation has been found in about 30% of KD patients in the acute stage, although mostly in the transient form. Diminishing the occurrence and regression of CAL is a vital part of treating KD. In this review article, I demonstrate the clinical method to prevent CAL formation used at the Kawasaki Disease Center in Taiwan.
川崎病（KD）是一种主要影响中小血管的系统性血管炎，最常见于5岁以下儿童。尽管其病因不明，但在发展中国家，川崎病一直是最常见的后天性心脏病。近几十年来，包括日本、韩国和中国在内的许多国家，其发病率都有所上升。川崎病最严重的并发症是冠状动脉病变（CAL），包括扩张、瘘管、动脉瘤、动脉重塑、狭窄和闭塞。在未接受静脉注射免疫球蛋白（IVIG）治疗的川崎病患者中，20%-25%会出现动脉瘤形成，而接受治疗的患者中这一比例为3%-5%。在急性期，约30%的川崎病患者会出现冠状动脉扩张，不过大多为短暂性。减少冠状动脉病变的发生和消退是治疗川崎病的关键部分。在这篇综述文章中，我展示了台湾川崎病中心用于预防冠状动脉病变形成的临床方法。
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