Institute of Neurology, UCL, London, UK.
Neuroscience Laboratory, Department of Neurology, China Medical University Hospital, Taichung, Taiwan.
Parkinsonism Relat Disord. 2017 Sep;42:61-65. doi: 10.1016/j.parkreldis.2017.06.011. Epub 2017 Jun 20.
Colonic diverticular disease is a chronic gastrointestinal disorder. Previous studies have suggested that chronic gastrointestinal tract is involved in the pathophysiology of Parkinson's disease.
This study investigated the potential link between colonic diverticular disease and risk of Parkinson's disease.
Data in this nationwide population-based cohort study were obtained from the National Health Insurance Research Database. Patients with colonic diverticular disease were identified from among 23.22 million insured Taiwanese residents who had been diagnosed between 2000 and 2005 and were aged ≥20 years (n = 23367). The comparison cohort included patients without colonic diverticular disease, matched by sex, age, and all comorbidities with the colonic diverticular disease patients cohort (n = 23367). Using univariable and multivariable Cox proportional hazard regression models, we estimated the adjusted hazard ratio (aHR) for PD with a 95% confidence interval (CI) after adjusting for age, sex, and all of comorbidities.
The risk of Parkinson's disease was higher in the CDD cohort than in the comparison cohort (HR = 1.27, 95%CI = 1.10-1.47). Compared with patients aged ≥65 years without CDD, the CDD patients in the equal age group had a 1.25-fold increased risk of PD (95% CI = 1.07-1.46).
Colonic diverticular disease may be associated with an increased risk of Parkinson's disease. Thus, the risk of this neurodegenerative disease should be considered in patients with colonic diverticular disease.
结肠憩室病是一种慢性胃肠道疾病。先前的研究表明，慢性胃肠道与帕金森病的病理生理学有关。
本研究探讨结肠憩室病与帕金森病风险之间的潜在联系。
本全国性基于人群的队列研究的数据来自国家健康保险研究数据库。在 2000 年至 2005 年间，2322 万被保险人中诊断出患有结肠憩室病的患者（n=23367），年龄≥20 岁。对照组包括没有结肠憩室病的患者，与结肠憩室病患者队列按性别、年龄和所有合并症相匹配（n=23367）。使用单变量和多变量 Cox 比例风险回归模型，我们估计了调整后的帕金森病风险比（aHR），95%置信区间（CI）是在调整年龄、性别和所有合并症后得出的。
与对照组相比，CDD 队列患帕金森病的风险更高（HR=1.27，95%CI=1.10-1.47）。与无 CDD 的≥65 岁患者相比，年龄相等的 CDD 患者患 PD 的风险增加了 1.25 倍（95%CI=1.07-1.46）。
结肠憩室病可能与帕金森病的风险增加有关。因此，在患有结肠憩室病的患者中应考虑这种神经退行性疾病的风险。
