Department of Preventive Veterinary Medicine, College of Veterinary Medicine, Northwest A&F University, Yangling, Shaanxi, China; Scientific Observing and Experimental Station of Veterinary Pharmacology and Diagnostic Technology, Ministry of Agriculture, Yangling, Shaanxi, China.
Department of Preventive Veterinary Medicine, College of Veterinary Medicine, Northwest A&F University, Yangling, Shaanxi, China; Scientific Observing and Experimental Station of Veterinary Pharmacology and Diagnostic Technology, Ministry of Agriculture, Yangling, Shaanxi, China.
Trends Microbiol. 2017 Dec;25(12):968-979. doi: 10.1016/j.tim.2017.06.001. Epub 2017 Jun 23.
PRRSV (porcine reproductive and respiratory syndrome virus) is a major economically significant pathogen that has adversely impacted the global swine industry for almost 30 years. Currently PRRSV is estimated to cause losses of almost US$600 million per year in the USA. Except for new mutants that continually emerge during PRRSV outbreaks, our understanding of the virology, origin, and evolution of PRRSV and the host's immune response are largely inadequate. Such limited knowledge impedes development of effective methods to eradicate this virus. In this review, we systematically describe recent advances in anti-PRRSV research, especially focusing on those techniques with the potential to transform current anti-PRRSV strategies. Furthermore, a combination of these new techniques may provide creative insights to guide future PRRSV control and prevention.
猪繁殖与呼吸综合征病毒（PRRSV）是一种主要的经济重要病原体，近 30 年来一直对全球养猪业造成不利影响。目前，PRRSV 估计每年在美国造成近 6 亿美元的损失。除了在 PRRSV 爆发期间不断出现的新突变体外，我们对 PRRSV 的病毒学、起源和进化以及宿主免疫反应的了解还远远不够。这种知识的局限性阻碍了有效根除这种病毒的方法的发展。在这篇综述中，我们系统地描述了抗 PRRSV 研究的最新进展，特别是那些具有改变当前抗 PRRSV 策略潜力的技术。此外，这些新技术的结合可能为指导未来 PRRSV 的控制和预防提供创造性的见解。
