Kingston Craig, Medinger Michael, Banderet-Uglioni Florian, Bassetti Stefano, Bargetzi Mario, Haubitz Sebastian, Fux Christoph A, Bättig Veronika, Goldenberger Daniel, Passweg Jakob, Heizmann Marc
Division of Internal Medicine, Department of Medicine, University Hospital Basel, and University of Basel, Basel, Switzerland.
Division of Internal Medicine, Department of Medicine, University Hospital Basel, and University of Basel, Basel, Switzerland; Division of Hematology, Department of Medicine, University Hospital Basel and University of Basel, Basel, Switzerland.
Int J Infect Dis. 2017 Aug;61:103-106. doi: 10.1016/j.ijid.2017.06.017. Epub 2017 Jun 23.
Sporopachydermia cereana is a rare yeast found in necrotic cactus tissue, predominantly in the Americas. Infection in humans with clinical data has only been reported in four patients so far, all of whom died, either directly from the pathogen or from other complications of immunosuppression. Treatment of the yeast is complicated by difficulties in identification of the pathogen with conventional diagnostic techniques and by intrinsic resistance to echinocandins. The first patient to survive a disseminated infection with S. cereana is presented herein. The patient had acute myeloid leukemia and was treated successfully with antifungal therapy and subsequently underwent a successful allogeneic hematopoietic stem cell transplantation.
仙人掌孢皮菌是一种罕见的酵母，主要在美洲的坏死仙人掌组织中发现。迄今为止，仅有4例有临床数据的人类感染病例报告，所有患者均死亡，要么直接死于病原体，要么死于免疫抑制的其他并发症。由于传统诊断技术难以鉴定病原体以及该酵母对棘白菌素具有固有抗性，其治疗变得复杂。本文介绍了首例播散性仙人掌孢皮菌感染存活的患者。该患者患有急性髓系白血病，接受抗真菌治疗后成功治愈，随后进行了成功的异基因造血干细胞移植。
