脑研究中的定量正电子发射断层扫描技术。

Quantitative positron emission tomography in brain research.

作者信息

Heurling Kerstin, Leuzy Antoine, Jonasson My, Frick Andreas, Zimmer Eduardo R, Nordberg Agneta, Lubberink Mark

机构信息

Wallenberg Centre for Molecular and Translational Medicine and the Department of Psychiatry and Neurochemistry, University of Gothenburg, Sweden; Department of Surgical Sciences, Uppsala University, Uppsala, Sweden.

Department Neurobiology, Care Sciences and Society, Division of Translational Alzheimer Neurobiology, Karolinska Institutet, Stockholm, Sweden.

出版信息

Brain Res. 2017 Sep 1;1670:220-234. doi: 10.1016/j.brainres.2017.06.022. Epub 2017 Jun 23.

DOI:10.1016/j.brainres.2017.06.022

PMID:28652218

Abstract

The application of positron emission tomography (PET) in brain research has increased substantially during the past 20years, and is still growing. PET provides a unique insight into physiological and pathological processes in vivo. In this article we introduce the fundamentals of PET, and the methods available for acquiring quantitative estimates of the parameters of interest. A short introduction to different areas of application is also given, including basic research of brain function and in neurology, psychiatry, drug receptor occupancy studies, and its application in diagnostics of neurodegenerative disorders such as Alzheimer's disease and Parkinson's disease. Our aim is to inform the unfamiliar reader of the underlying basics and potential applications of PET, hoping to inspire the reader into considering how the technique could be of benefit for his or her own research.

摘要

在过去20年中，正电子发射断层扫描（PET）在脑研究中的应用大幅增加，并且仍在增长。PET为体内生理和病理过程提供了独特的见解。在本文中，我们介绍了PET的基本原理，以及用于获取感兴趣参数定量估计值的可用方法。还简要介绍了不同的应用领域，包括脑功能基础研究以及在神经病学、精神病学、药物受体占有率研究中的应用，及其在阿尔茨海默病和帕金森病等神经退行性疾病诊断中的应用。我们的目的是让不熟悉的读者了解PET的基本原理和潜在应用，希望能激发读者思考该技术如何能为其自身研究带来益处。