Department of Radiology, Mayo Clinic, Rochester, MN, USA.
Neurotherapeutics. 2021 Apr;18(2):661-672. doi: 10.1007/s13311-021-01030-9. Epub 2021 Mar 15.
In the past decades, many neuroimaging studies have aimed to improve the scientific understanding of human neurodegenerative diseases using MRI and PET. This article is designed to provide an overview of the major classes of brain imaging and how/why they are used in this line of research. It is intended as a primer for individuals who are relatively unfamiliar with the methods of neuroimaging research to gain a better understanding of the vocabulary and overall methodologies. It is not intended to describe or review any research findings for any disease or biology, but rather to broadly describe the imaging methodologies that are used in conducting this neurodegeneration research. We will also review challenges and strategies for analyzing neuroimaging data across multiple sites and studies, i.e., harmonization and standardization of imaging data for multi-site and meta-analyses.
在过去的几十年中，许多神经影像学研究旨在利用 MRI 和 PET 来提高对人类神经退行性疾病的科学认识。本文旨在概述主要的脑成像类别，以及它们在该研究领域中的应用方式和原因。对于那些对神经影像学研究方法相对不熟悉的人来说，这是一个入门读物，旨在帮助他们更好地理解相关词汇和整体方法。本文不打算描述或回顾任何疾病或生物学方面的研究结果，而是广泛描述用于进行神经退行性变研究的成像方法。我们还将回顾在多个地点和研究中分析神经影像学数据的挑战和策略，即多地点和荟萃分析中对成像数据进行协调和标准化。
