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Beyond binding change: the molecular mechanism of ATP hydrolysis by F-ATPase and its biochemical consequences.超越结合变化：F-ATP 合酶催化 ATP 水解的分子机制及其生化后果
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F-ATPase Rotary Mechanism: Interpreting Results of Diverse Experimental Modes With an Elastic Coupling Theory.F型ATP合酶的旋转机制：用弹性偶联理论解释不同实验模式的结果
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本文引用的文献

1
Theory of single-molecule controlled rotation experiments, predictions, tests, and comparison with stalling experiments in F1-ATPase.单分子控制旋转实验的理论、预测、测试以及与F1-ATP合酶中停滞实验的比较。
Proc Natl Acad Sci U S A. 2016 Oct 25;113(43):12029-12034. doi: 10.1073/pnas.1611601113. Epub 2016 Oct 10.
2
Theory for rates, equilibrium constants, and Brønsted slopes in F1-ATPase single molecule imaging experiments.F1-ATP酶单分子成像实验中速率、平衡常数和布朗斯特斜率的理论
Proc Natl Acad Sci U S A. 2015 Nov 17;112(46):14230-5. doi: 10.1073/pnas.1518489112. Epub 2015 Oct 19.
3
Dissecting the role of the γ-subunit in the rotary-chemical coupling and torque generation of F1-ATPase.剖析γ亚基在F1-ATP合酶的旋转-化学偶联及扭矩产生中的作用。
Proc Natl Acad Sci U S A. 2015 Mar 3;112(9):2746-51. doi: 10.1073/pnas.1500979112. Epub 2015 Feb 17.
4
Two-state theory of binned photon statistics for a large class of waiting time distributions and its application to quantum dot blinking.一大类等待时间分布的分箱光子统计的二态理论及其在量子点闪烁中的应用。
J Chem Phys. 2014 Jun 14;140(22):224110. doi: 10.1063/1.4881460.
5
Controlled rotation of the F₁-ATPase reveals differential and continuous binding changes for ATP synthesis.控制 F₁-ATP 酶的旋转揭示了 ATP 合成的不同和连续的结合变化。
Nat Commun. 2012;3:1022. doi: 10.1038/ncomms2026.
6
Mechanical modulation of catalytic power on F1-ATPase.F1-ATP 酶催化性能的机械调控。
Nat Chem Biol. 2011 Nov 20;8(1):86-92. doi: 10.1038/nchembio.715.
7
Two rotary motors in F-ATP synthase are elastically coupled by a flexible rotor and a stiff stator stalk.F-ATP 合酶中的两个旋转电机通过柔性转子和刚性定子茎弹性耦合。
Proc Natl Acad Sci U S A. 2011 Mar 8;108(10):3924-9. doi: 10.1073/pnas.1011581108. Epub 2011 Feb 22.
8
Phosphate release in F1-ATPase catalytic cycle follows ADP release.在 F1-ATP 酶催化循环中，磷酸盐的释放紧随 ADP 释放之后。
Nat Chem Biol. 2010 Nov;6(11):814-20. doi: 10.1038/nchembio.443. Epub 2010 Sep 26.
9
Correlations between subsequent blinking events in single quantum dots.单个量子点中后续闪烁事件之间的相关性。
Nano Lett. 2010 Aug 11;10(8):2761-5. doi: 10.1021/nl100253r.
10
Torque generation and elastic power transmission in the rotary F(O)F(1)-ATPase.旋转式F（O）F（1）-ATP合酶中的扭矩产生与弹性功率传输
Nature. 2009 May 21;459(7245):364-70. doi: 10.1038/nature08145.

在 F-ATP 酶的单分子控制旋转实验中长结合事件的理论。

Theory of long binding events in single-molecule-controlled rotation experiments on F-ATPase.

机构信息

Noyes Laboratory of Chemical Physics, California Institute of Technology, Pasadena, CA 91125

出版信息

Proc Natl Acad Sci U S A. 2017 Jul 11;114(28):7272-7277. doi: 10.1073/pnas.1705960114. Epub 2017 Jun 26.

DOI:10.1073/pnas.1705960114
PMID:28652332
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5514755/
Abstract

The theory of elastic group transfer for the binding and release rate constants for nucleotides in F-ATPase as a function of the rotor angle is further extended in several respects. () A method is described for predicting the experimentally observed lifetime distribution of long binding events in the controlled rotation experiments by taking into account the hydrolysis and synthesis reactions occurring during these events. () A method is also given for treating the long binding events in the experiments and obtaining the rate constants for the hydrolysis and synthesis reactions occurring during these events. () The theory in the previous paper is given in a symmetric form, an extension that simplifies the application of the theory to experiments. It also includes a theory-based correction of the reported "on" and "off" rates by calculating the missed events. A near symmetry of the data about the angle of -40° and a "turnover" in the binding rate data vs. rotor angle for angles greater than [Formula: see text]40° is also discussed.

摘要

将弹性基团转移理论进一步扩展到 F-ATPase 中核苷酸的结合和解离速率常数与转子角度的关系的几个方面。()描述了一种方法，通过考虑在这些事件中发生的水解和合成反应，来预测在受控旋转实验中观察到的长结合事件的实验观测到的寿命分布。()还给出了一种处理实验中长结合事件并获得这些事件中发生的水解和合成反应的速率常数的方法。()前一篇论文中的理论以对称形式给出，这种扩展简化了理论在实验中的应用。它还包括通过计算错过的事件，对报告的“开”和“关”速率进行基于理论的修正。还讨论了关于角度-40°的数据的接近对称性，以及大于[公式：见文本]40°的转子角度的结合速率数据的“翻转”。