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High biologically effective dose radiation therapy using brachytherapy in combination with external beam radiotherapy for high-risk prostate cancer.使用近距离放射疗法联合外照射放疗对高危前列腺癌进行高生物有效剂量放射治疗。
J Contemp Brachytherapy. 2017 Feb;9(1):1-6. doi: 10.5114/jcb.2017.66072. Epub 2017 Feb 20.
2
Decline in acute urinary toxicities with increased institutional experience: 15-year experience of permanent seed prostate brachytherapy in a single Australasian institution.随着机构经验增加，急性泌尿毒性降低：一家澳大利亚机构15年永久性籽源前列腺近距离放射治疗经验
Brachytherapy. 2017 Mar-Apr;16(2):313-322. doi: 10.1016/j.brachy.2016.11.010. Epub 2016 Dec 21.
3
Chronic Prostate Inflammation is Associated with Severity and Progression of Benign Prostatic Hyperplasia, Lower Urinary Tract Symptoms and Risk of Acute Urinary Retention.慢性前列腺炎与良性前列腺增生的严重程度和进展、下尿路症状以及急性尿潴留风险相关。
J Urol. 2016 Nov;196(5):1493-1498. doi: 10.1016/j.juro.2016.06.090. Epub 2016 Jul 1.
4
Urinary and Rectal Toxicity Profiles After Permanent Iodine-125 Implant Brachytherapy in Japanese Men: Nationwide J-POPS Multi-institutional Prospective Cohort Study.日本男性永久性碘-125植入近距离放射治疗后的泌尿和直肠毒性特征：全国性J-POPS多机构前瞻性队列研究。
Int J Radiat Oncol Biol Phys. 2015 Sep 1;93(1):141-9. doi: 10.1016/j.ijrobp.2015.05.014. Epub 2015 May 15.
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Long-Term Efficacy and Toxicity of Low-Dose-Rate ¹²⁵I Prostate Brachytherapy as Monotherapy in Low-, Intermediate-, and High-Risk Prostate Cancer.低剂量率¹²⁵I 前列腺近距离放疗作为低、中、高危前列腺癌单一疗法的长期疗效和毒性。
Int J Radiat Oncol Biol Phys. 2015 Jul 15;92(4):884-93. doi: 10.1016/j.ijrobp.2015.02.047. Epub 2015 May 8.
6
Use of alpha-1 adrenoceptor antagonists in patients who underwent low-dose-rate brachytherapy for prostate cancer - a randomized controlled trial of silodosin versus naftopidil.α1肾上腺素能受体拮抗剂在接受低剂量率近距离放射治疗的前列腺癌患者中的应用——西洛多辛与萘哌地尔的随机对照试验
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局限性前列腺癌永久性碘-125粒子植入治疗后长期排尿障碍的预测因素

Predictive Factors for Prolonged Urination Disorder After Permanent I Brachytherapy for Localized Prostate Cancer.

作者信息

Mori Hidehisa, Fukumori Tomoharu, Daizumoto Kei, Tsuda Megumi, Kusuhara Yoshihito, Fukawa Tomoya, Yamamoto Yasuyo, Yamaguchi Kunihisa, Takahashi Masayuki, Kubo Akiko, Kawanaka Takashi, Furutani Shunsuke, Ikushima Hitoshi, Kanayama Hiro-Omi

机构信息

Department of Urology, Institute of Health Biosciences, The University of Tokushima Graduate School, Tokushima, Japan

Department of Urology, Institute of Health Biosciences, The University of Tokushima Graduate School, Tokushima, Japan.

出版信息

In Vivo. 2017 Jul-Aug;31(4):755-761. doi: 10.21873/invivo.11127.

DOI:10.21873/invivo.11127
PMID:28652453
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5566936/
Abstract

BACKGROUND

We assessed the change in LUTS after prostate brachytherapy to reveal factors for prolonged urination disorder.

MATERIALS AND METHODS

Four hundred and four patients received prostate brachytherapy at our institution and were followed-up for at least 2 years. We evaluated the correlation of mean IPSS changes and clinical factors. Using multivariate analysis, we also evaluated clinical factors with potential to delay IPSS resolution.

RESULTS

In cases with prostate volume more than 30 cm, radiation dose to 90% of prostate volume (D90) more than 160 Gy, and radiation dose to 30% of the urethral volume (UD30) more than 240 Gy, mean IPSS levels were significantly higher, even 30 months after treatment. On multivariate analysis, baseline IPSS more than 8 points and D90 more than 160 Gy were significant predictors for delayed IPSS resolution.

CONCLUSION

Our data suggest that higher baseline IPSS and higher D90 were predictors for prolonged urination disorder.

摘要

背景

我们评估了前列腺近距离放射治疗后下尿路症状（LUTS）的变化，以揭示导致排尿障碍持续时间延长的因素。

材料与方法

404例患者在我院接受了前列腺近距离放射治疗，并进行了至少2年的随访。我们评估了平均国际前列腺症状评分（IPSS）变化与临床因素之间的相关性。通过多因素分析，我们还评估了可能延迟IPSS恢复的临床因素。

结果

在前列腺体积大于30 cm³、前列腺体积90%的辐射剂量（D90）大于160 Gy以及尿道体积30%的辐射剂量（UD30）大于240 Gy的病例中，即使在治疗后30个月，平均IPSS水平仍显著更高。多因素分析显示，基线IPSS大于8分和D90大于160 Gy是IPSS恢复延迟的显著预测因素。

结论

我们的数据表明，较高的基线IPSS和较高的D90是排尿障碍持续时间延长的预测因素。