Uno Masaaki, Toi Hiroyuki, Hirai Satoshi
Department of Neurosurgery, Kawasaki Medical School.
Neurol Med Chir (Tokyo). 2017 Aug 15;57(8):402-409. doi: 10.2176/nmc.ra.2016-0337. Epub 2017 Jun 26.
As the world population becomes progressively older, the overall incidence of chronic subdural hematoma (CSDH) is increasing. Peak age of onset for CSDH has also increased, and recently the 80-year-old level has a peak. Many patients with CSDH have had prior treatment with anticoagulants and antiplatelet drugs, which have an accompanying risk of CSDH. In elderly patients with CSDH, symptoms of cognitive change (memory disturbance, urinary incontinence, and decreased activity) and disturbance of consciousness at admission were more frequent compared to younger patients with CSDH. The literature actually offers conflicting advice regarding CSDH treatment; however, burr hole surgery with drainage under local anesthesia is the most common surgical procedure, even in elderly patients. The recurrence rate of CSDH has not decreased over recent decades, and it has ranged from 0.36-33.3%. Outcomes in patients over 75 years old was significantly worse than for those younger than 75. Moreover, long-term outcomes for elderly patients with CSDH are poor. CSDH in the elderly is no longer a benign disease. In the future, it will be important for us to understand the mechanisms of onset and recurrence of CSDH and to develop more effective medical treatments and noninvasive surgical techniques for elderly patients.
随着世界人口日益老龄化,慢性硬膜下血肿(CSDH)的总体发病率正在上升。CSDH的发病高峰年龄也有所增加,最近80岁年龄段出现了发病高峰。许多CSDH患者此前曾接受过抗凝剂和抗血小板药物治疗,这些治疗伴随着CSDH的风险。与年轻的CSDH患者相比,老年CSDH患者在入院时出现认知改变(记忆障碍、尿失禁和活动减少)和意识障碍的症状更为常见。实际上,文献中对于CSDH治疗的建议相互矛盾;然而,即使在老年患者中,局部麻醉下钻孔引流手术仍是最常见的外科手术。近几十年来,CSDH的复发率并未降低,范围在0.36%-33.3%之间。75岁以上患者的预后明显比75岁以下患者差。此外,老年CSDH患者的长期预后不佳。老年CSDH已不再是一种良性疾病。未来,了解CSDH的发病和复发机制,并为老年患者开发更有效的药物治疗和非侵入性手术技术对我们来说将非常重要。