• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

严重非典型带状疱疹作为伴有原始细胞增多的难治性贫血（RAEB II型）的致命骨髓增生异常综合征的首发症状。

Severe atypical herpes zoster as an initial symptom of fatal myelodysplastic syndrome with refractory anemia and blast excess (RAEB II).

作者信息

Wollina Uwe, Hansel Gesina, Baunacke Anja, Tchernev Georgi

机构信息

Department of Dermatology and Allergology, Academic Teaching Hospital Dresden-Friedrichstadt, Dresden, Germany.

Department of Dermatology and Dermatologic Surgery, Medical Institute of Ministry of Interior (MVR), Sofia, Bulgaria.

出版信息

Clin Cosmet Investig Dermatol. 2017 May 18;10:195-198. doi: 10.2147/CCID.S133966. eCollection 2017.

DOI:10.2147/CCID.S133966
PMID:28652792
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5478159/
Abstract

Herpes zoster is a common disease caused due to varicella zoster virus (VZV) infection with increasing incidence by age. If the patient has a severe, extended, or treatment-recalcitrant course of herpes zoster, this must be a red flag to search for underlying pathologies. Here, we report about a 64-year-old male patient with diabetes, who came to our emergency department because of general malaise, fever, chills, and a pronounced nuchal and facial swelling on the left side. Based on herpetiform-grouped vesicles and yellowish crusts, an impetiginized facial herpes zoster was diagnosed, and combined antiviral and antibiotic treatment was initiated. He was HIV negative. Despite intensified treatment, his situation worsened. We observed blasts in peripheral blood, but bone marrow biopsy was initially denied. Some days later after deterioration of his disease, he accepted further diagnostics. A myelodysplastic syndrome with blast excess (refractory anemia and blast excess II, RAEB II) could be confirmed. The following translocations were detected: t(2;12)(p13; q13) and t(6;9)(p22;q34). REAB II has an unfortunate prognosis. Cytoreductive treatment was initiated by the hematooncologist. Unfortunately, the patient deceased due to septic shock.

摘要

带状疱疹是一种由水痘-带状疱疹病毒（VZV）感染引起的常见疾病，其发病率随年龄增长而增加。如果患者患有严重、广泛或治疗抵抗性的带状疱疹病程，这必须是寻找潜在病理状况的警示信号。在此，我们报告一名64岁的糖尿病男性患者，他因全身不适、发热、寒战以及左侧颈部和面部明显肿胀而前来我们的急诊科。基于疱疹样成群水疱和淡黄色痂皮，诊断为脓疱化面部带状疱疹，并开始联合抗病毒和抗生素治疗。他的HIV检测为阴性。尽管强化了治疗，他的病情仍恶化。我们在外周血中观察到原始细胞，但最初拒绝进行骨髓活检。在他的病情恶化几天后，他接受了进一步诊断。证实为伴有原始细胞增多的骨髓增生异常综合征（难治性贫血伴原始细胞增多II型，RAEB II）。检测到以下易位：t(2;12)(p13; q13)和t(6;9)(p22;q34)。RAEB II预后不佳。血液肿瘤学家开始进行减瘤治疗。不幸的是，患者因感染性休克死亡。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a1a8/5478159/f24a4570a9a2/ccid-10-195Fig4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a1a8/5478159/ebcef15a8330/ccid-10-195Fig1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a1a8/5478159/58e4f5a45184/ccid-10-195Fig2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a1a8/5478159/98ab1097f8c0/ccid-10-195Fig3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a1a8/5478159/f24a4570a9a2/ccid-10-195Fig4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a1a8/5478159/ebcef15a8330/ccid-10-195Fig1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a1a8/5478159/58e4f5a45184/ccid-10-195Fig2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a1a8/5478159/98ab1097f8c0/ccid-10-195Fig3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a1a8/5478159/f24a4570a9a2/ccid-10-195Fig4.jpg

相似文献

1
Severe atypical herpes zoster as an initial symptom of fatal myelodysplastic syndrome with refractory anemia and blast excess (RAEB II).严重非典型带状疱疹作为伴有原始细胞增多的难治性贫血（RAEB II型）的致命骨髓增生异常综合征的首发症状。
Clin Cosmet Investig Dermatol. 2017 May 18;10:195-198. doi: 10.2147/CCID.S133966. eCollection 2017.
2
Genital Herpes Zoster as Possible Indicator of HIV Infection.生殖器带状疱疹可能是艾滋病毒感染的指标。
Acta Dermatovenerol Croat. 2018 Dec;26(4):337-338.
3
An adult co-presented with varicella and herpes zoster caused by varicella zoster virus genotype J, China: a case report.中国一例成人水痘和由水痘带状疱疹病毒基因型 J 引起的带状疱疹共同发生的病例报告。
BMC Infect Dis. 2020 Jun 29;20(1):454. doi: 10.1186/s12879-020-05192-3.
4
Disseminated zoster in an adult patient with extensive burns: a case report.成人广泛烧伤患者的播散性带状疱疹：病例报告。
Virol J. 2019 May 23;16(1):68. doi: 10.1186/s12985-019-1179-8.
5
Immunologic characteristics and prognosis of myelodysplastic syndrome new subtype: refractory anemia with excess blasts-II.骨髓增生异常综合征新亚型：伴过多原始细胞的难治性贫血-II的免疫特征及预后
Zhongguo Shi Yan Xue Ye Xue Za Zhi. 2009 Feb;17(1):111-6.
6
Translocation t(6;9)(p22.3;q34) in myelodysplastic syndrome--refractory anemia with excess blasts.骨髓增生异常综合征——伴原始细胞增多的难治性贫血中的6号和9号染色体易位t(6;9)(p22.3;q34)
Cancer Genet Cytogenet. 1987 Nov;29(1):135-8. doi: 10.1016/0165-4608(87)90040-9.
7
An Atypical Rash in Disseminated Herpes Zoster: A Case Report.播散性带状疱疹的非典型皮疹：一例报告
Cureus. 2023 Jan 4;15(1):e33359. doi: 10.7759/cureus.33359. eCollection 2023 Jan.
8
[Myelodysplastic syndromes (MDS). Aspects of hematopathologic diagnosis].[骨髓增生异常综合征（MDS）。血液病理学诊断的各个方面]
Pathologe. 2000 Jan;21(1):1-15. doi: 10.1007/s002920050001.
9
[Non-Hodgkin's lymphoma complicated by recurrent intractable generalized herpes zoster responsive to long-term acyclovir therapy].[非霍奇金淋巴瘤合并复发性难治性泛发性带状疱疹，对长期阿昔洛韦治疗有效]
Kansenshogaku Zasshi. 1999 Apr;73(4):341-5. doi: 10.11150/kansenshogakuzasshi1970.73.341.
10
Refractory anaemia with excess of blasts (RAEB): analysis of reclassification according to the WHO proposals.伴有过多原始细胞的难治性贫血（RAEB）：根据世界卫生组织建议进行重新分类的分析
Br J Haematol. 2006 Jan;132(2):162-7. doi: 10.1111/j.1365-2141.2005.05853.x.

引用本文的文献

1
: A Review of Clinical Manifestations and Management.临床特征与管理综述
Viruses. 2022 Jan 19;14(2):192. doi: 10.3390/v14020192.

本文引用的文献

1
European consensus-based (S2k) Guideline on the Management of Herpes Zoster - guided by the European Dermatology Forum (EDF) in cooperation with the European Academy of Dermatology and Venereology (EADV), Part 1: Diagnosis.欧洲基于共识的（S2k）带状疱疹管理指南——由欧洲皮肤病学论坛（EDF）与欧洲皮肤性病学会（EADV）合作指导，第1部分：诊断
J Eur Acad Dermatol Venereol. 2017 Jan;31(1):9-19. doi: 10.1111/jdv.13995. Epub 2016 Nov 2.
2
Changes in the Updated 2016: WHO Classification of the Myelodysplastic Syndromes and Related Myeloid Neoplasms.2016年更新版：世界卫生组织髓系发育异常综合征及相关髓系肿瘤分类的变化。
Clin Lymphoma Myeloma Leuk. 2016 Nov;16(11):607-609. doi: 10.1016/j.clml.2016.08.005. Epub 2016 Aug 12.
3
European consensus-based (S2k) Guideline on the Management of Herpes Zoster - guided by the European Dermatology Forum (EDF) in cooperation with the European Academy of Dermatology and Venereology (EADV), Part 2: Treatment.
欧洲基于共识（S2k）的带状疱疹管理指南——由欧洲皮肤病学论坛（EDF）与欧洲皮肤性病学会（EADV）合作制定，第2部分：治疗
J Eur Acad Dermatol Venereol. 2017 Jan;31(1):20-29. doi: 10.1111/jdv.13957. Epub 2016 Nov 2.
4
[Herpes zoster and postherpetic neuralgia].[带状疱疹及带状疱疹后神经痛]
Hautarzt. 2016 Aug;67(8):653-65. doi: 10.1007/s00105-016-3834-y.
5
Interactions and relevance of blast percentage and treatment strategy among younger and older patients with acute myeloid leukemia (AML) and myelodysplastic syndrome (MDS).急性髓系白血病（AML）和骨髓增生异常综合征（MDS）的年轻和老年患者中原始细胞百分比与治疗策略的相互作用及相关性。
Am J Hematol. 2016 Feb;91(2):227-32. doi: 10.1002/ajh.24252.
6
Community-acquired infections and their association with myeloid malignancies.社区获得性感染及其与髓系恶性肿瘤的关系。
Cancer Epidemiol. 2014 Feb;38(1):56-61. doi: 10.1016/j.canep.2013.10.009. Epub 2013 Nov 22.
7
The t(6;9)(p22;q34) in myeloid neoplasms: a retrospective study of 16 cases.髓系肿瘤中的t(6;9)(p22;q34)：16例回顾性研究
Cancer Genet Cytogenet. 2010 Dec;203(2):297-302. doi: 10.1016/j.cancergencyto.2010.08.012.
8
Analysis of prognostic factors in patients with refractory anemia with excess of blasts (RAEB) reclassified according to WHO proposal.根据世界卫生组织提议重新分类的伴有过多原始细胞的难治性贫血（RAEB）患者的预后因素分析。
Leuk Res. 2009 Mar;33(3):391-4. doi: 10.1016/j.leukres.2008.06.033. Epub 2008 Aug 3.
9
[Differential diagnosis of facial skin swellings (author's transl)].面部皮肤肿胀的鉴别诊断（作者译）
HNO. 1979 Apr;27(4):129-37.