Hansen Tine Maria, Mark Esben Bolvig, Olesen Søren Schou, Gram Mikkel, Frøkjær Jens Brøndum, Drewes Asbjørn Mohr
Mech-Sense, Department of Radiology, Aalborg University Hospital.
Department of Clinical Medicine, Aalborg University.
J Pain Res. 2017 Jun 7;10:1401-1409. doi: 10.2147/JPR.S132909. eCollection 2017.
The aim of the present study was to characterize the cortical source generators evoked by experimental tonic pain.
Electroencephalography (EEG) was recorded on two separate days during rest and with immersion of the hand in ice water for 2 minutes (cold pressor test). Exact low-resolution brain electromagnetic tomography source localization was performed in 31 healthy volunteers to characterize the cortical source generators.
Reliability was high in all eight frequency bands during rest and cold pressor conditions (intraclass coefficients =0.47-0.83 in the cingulate and insula). Tonic pain increased cortical activities in the delta (1-4 Hz), theta (4-8 Hz), beta1 (12-18 Hz), beta2 (18-24 Hz), beta3 (24-32 Hz), and gamma (32-60 Hz) bands (all <0.011) in widespread areas mainly in the limbic system, whereas decreased cortical activities were found in cingulate and pre- and postcentral gyri in the alpha2 (10-12 Hz) band (=0.007). The pain intensity was correlated with cingulate activity in the beta2, beta3, and gamma bands (all <0.04).
Source localization of EEG is a reliable method to estimate cortical source generators. Activities in different brain regions, mainly in the limbic system, showed fluctuations in various frequency bands. Cingulate changes were correlated with pain intensity.
This method might add information to the objective assessment of the cortical pain response in future experimental pain studies.
本研究旨在描述实验性紧张性疼痛诱发的皮质源发生器特征。
在静息状态以及将手浸入冰水中2分钟（冷加压试验）这两个不同的日子记录脑电图（EEG）。对31名健康志愿者进行精确低分辨率脑电磁断层扫描源定位，以描述皮质源发生器特征。
在静息和冷加压条件下，所有八个频段的可靠性都很高（扣带回和脑岛的组内相关系数=0.47 - 0.83）。紧张性疼痛使广泛区域（主要在边缘系统）的δ波（1 - 4赫兹）、θ波（4 - 8赫兹）、β1波（12 - 18赫兹）、β2波（18 - 24赫兹）、β3波（24 - 32赫兹）和γ波（32 - 60赫兹）频段的皮质活动增加（均<0.011），而在α2波（10 - 12赫兹）频段，扣带回以及中央前回和中央后回的皮质活动减少（=0.007）。疼痛强度与β2、β3和γ频段的扣带回活动相关（均<0.04）。
脑电图源定位是估计皮质源发生器的可靠方法。不同脑区（主要在边缘系统）的活动在各个频段呈现波动。扣带回的变化与疼痛强度相关。
该方法可能会为未来实验性疼痛研究中皮质疼痛反应的客观评估增添信息。
