钯催化的3-吲哚甲酰胺的区域选择性分子内直接芳基化反应：合成螺吲哚啉-3,3'-氧化吲哚和5,11-二氢-6H-吲哚并[3,2-c]喹啉-6-酮。
Pd-catalyzed regioselective intramolecular direct arylation of 3-indolecarboxamides: access to spiro-indoline-3,3'-oxindoles and 5,11-dihydro-6H-indolo[3,2-c]quinolin-6-ones.
作者信息
Xu Xiaobing, Liu Jianchao, Lu Lin, Wang Furong, Yin Biaolin
机构信息
Key Laboratory of Functional Molecular Engineering of Guangdong Province, School of Chemistry and Chemical Engineering, South China University of Technology, Guangzhou 510640, P. R. China.
出版信息
Chem Commun (Camb). 2017 Jul 6;53(55):7796-7799. doi: 10.1039/c7cc02256e.
PMID:28653060
Abstract
We report regioselective intramolecular direct C-3 and C-2 arylations of the indole rings of N-(o-bromophenyl)-3-indolecarboxamides for diastereospecific production of spiro-indoline-3,3'-oxindoles and 5,11-dihydro-6H-indolo[3,2-c]quinolin-6-ones, respectively, under different reaction conditions and possibly involving two different pathways.
摘要
我们报道了在不同反应条件下，N-(邻溴苯基)-3-吲哚甲酰胺的吲哚环分别进行区域选择性分子内直接C-3和C-2芳基化反应，以非对映体特异性地生成螺吲哚啉-3,3'-氧化吲哚和5,11-二氢-6H-吲哚并[3,2-c]喹啉-6-酮，且可能涉及两条不同的途径。
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