Department of Public Health and Primary Care, Academic Center for General Practice, Katholieke Universiteit Leuven (KU Leuven), Leuven, Belgium.
Institute of Health and Society, Université Catholique de Louvain (UCL), Clos Chapelle-aux-Champs 30, B.1.30.15, 1200, Brussels, Belgium.
Aging Clin Exp Res. 2018 May;30(5):507-516. doi: 10.1007/s40520-017-0792-x. Epub 2017 Jun 26.
Forced expiratory volume in 1 s over height cubed (FEV/Ht) is an FEV expression that uses no reference values and is independently associated with adverse outcomes in older adults. No studies have reported on the prognostic value of its decline over time in adults aged 80 and over.
To investigate the prognostic value of FEV/Ht decline for adverse outcomes in a cohort of adults aged 80 and over.
328 community-dwelling adults aged 80 and over of the BELFRAIL prospective cohort had two valid FEV measurements as part of their comprehensive geriatric assessment at baseline and follow-up (after 1.7 ± 0.21 years). Kaplan-Meier survival curves, Cox and logistic multivariable regression, assessed association of excessive decline of FEV/Ht (lowest quintile of percentage change) with all-cause mortality (3 years after follow-up assessment), time to first hospitalization (1 year), and new/ worsened disability in activities of daily living (ADL) at the follow-up assessment.
Participants with excessive FEV/Ht decline had increased adjusted hazard ratio for all-cause death 1.61 (95% CI 1.01-2.55) and first hospitalization 1.71 (1.08-2.71) and increased odds ratio for new/worsened ADL disability at follow-up 2.02 (1.10-3.68) compared to the rest of the study population.
Excessive, short-term decline in FEV/Ht was independently associated with all-cause mortality, time to first, unplanned hospitalization, and ADL disability in a cohort of adults aged 80 and over. This FEV expression should be further investigated in studies of longitudinal FEV change in older adults.
身高立方英尺的 1 秒用力呼气量（FEV/Ht）是一种不使用参考值的 FEV 表达，与老年人的不良结局独立相关。没有研究报告过 80 岁及以上成年人随时间推移 FEV/Ht 下降的预后价值。
研究 FEV/Ht 下降对 80 岁及以上成年人不良结局的预后价值。
BELFRAIL 前瞻性队列的 328 名 80 岁及以上的社区居住成年人在基线和随访时（随访后 1.7±0.21 年）进行了两次有效的 FEV 测量，作为其综合老年评估的一部分。Kaplan-Meier 生存曲线、Cox 和 logistic 多变量回归分析评估了 FEV/Ht 过度下降（百分比变化最低五分位数）与全因死亡率（随访后 3 年）、首次住院时间（1 年）和随访时新/恶化日常生活活动（ADL）残疾之间的关联。
与研究人群的其余部分相比，FEV/Ht 过度下降的参与者全因死亡的调整后危险比为 1.61（95%CI 1.01-2.55），首次住院的危险比为 1.71（1.08-2.71），随访时新/恶化 ADL 残疾的优势比为 2.02（1.10-3.68）。
在 80 岁及以上成年人队列中，FEV/Ht 的过度、短期下降与全因死亡率、首次、非计划性住院和 ADL 残疾独立相关。在老年人纵向 FEV 变化的研究中，应进一步研究这种 FEV 表达。
