铜催化原位生成的邻烯基芳基腈与双(频哪醇)二硼的硼化环化反应。
Copper-Catalyzed Borylative Cyclization of in Situ Generated o-Allenylaryl Nitriles with Bis(pinacolato)diboron.
机构信息
State Key Laboratory of Organometallic Chemistry, Shanghai Institute of Organic Chemistry, University of Chinese Academy of Sciences, Chinese Academy of Sciences , 345 Lingling Lu, Shanghai 200032, People's Republic of China.
出版信息
Org Lett. 2017 Jul 7;19(13):3398-3401. doi: 10.1021/acs.orglett.7b01355. Epub 2017 Jun 27.
A Cu-catalyzed cascade borylcupration/cyclization of in situ generated allene-nitriles with Bpin has been developed, which provides highly substituted 3-boryl-1-naphthylamines with excellent regioselectivity and wide functional group compatibility. It has been shown that, for the first time, the catalytically generated allylcopper species can be captured by a cyano group from a normal nitrile to furnish a carbocycle.
一种 Cu 催化的级联硼化/环化反应，利用原位生成的烯丙基腈与 Bpin 反应，提供了高取代的 3-硼基-1-萘基胺，具有极好的区域选择性和广泛的官能团兼容性。这表明，首次可以从正常腈中捕捉到催化生成的烯丙基铜物种，从而形成碳环。
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