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miR-144-3p 靶向 FosB 原癌基因，AP-1 转录因子亚基（FOSB），抑制 PANC-1 胰腺癌细胞的增殖、迁移和侵袭。

miR-144-3p Targets FosB Proto-oncogene, AP-1 Transcription Factor Subunit (FOSB) to Suppress Proliferation, Migration, and Invasion of PANC-1 Pancreatic Cancer Cells.

机构信息

The First Department of General Surgery, Daqing Oilfield General Hospital, Daqing, Heilongjiang, P.R. China.

出版信息

Oncol Res. 2018 Jun 11;26(5):683-690. doi: 10.3727/096504017X14982585511252. Epub 2017 Jun 24.

DOI:10.3727/096504017X14982585511252
PMID:28653602
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7844736/
Abstract

This study aimed to investigate the role of miR-144-3p in pancreatic cancer (PC) carcinogenesis and to explore the mechanism of its function in PC. miR-144-3p was downregulated in PC tissues and cells. miR-144-3p overexpression significantly inhibited PC cell proliferation, migration, and invasion. FosB proto-oncogene, AP-1 transcription factor subunit (FOSB) was a target gene of miR-144-3p. miR-144-3p could repress PC cell proliferation, migration, and invasion by inhibiting the expression of FOSB. In conclusion, miR-144-3p plays an important role in PC cell proliferation, migration, and invasion by targeting FOSB. miR-144-3p may provide a new target for the development of therapeutic agents against PC.

摘要

本研究旨在探讨 miR-144-3p 在胰腺癌 (PC) 发生发展中的作用，并探讨其在 PC 中的功能机制。miR-144-3p 在 PC 组织和细胞中下调。miR-144-3p 过表达显著抑制 PC 细胞增殖、迁移和侵袭。原癌基因 FosB、AP-1 转录因子亚基 (FOSB) 是 miR-144-3p 的靶基因。miR-144-3p 通过抑制 FOSB 的表达抑制 PC 细胞的增殖、迁移和侵袭。总之，miR-144-3p 通过靶向 FOSB 发挥重要作用，抑制 PC 细胞增殖、迁移和侵袭。miR-144-3p 可能为开发针对 PC 的治疗药物提供新的靶点。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e73e/7844736/093beab89e14/OR-26-683-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e73e/7844736/4c928f243d86/OR-26-683-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e73e/7844736/090a00978548/OR-26-683-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e73e/7844736/65eedff32cda/OR-26-683-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e73e/7844736/093beab89e14/OR-26-683-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e73e/7844736/4c928f243d86/OR-26-683-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e73e/7844736/090a00978548/OR-26-683-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e73e/7844736/65eedff32cda/OR-26-683-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e73e/7844736/093beab89e14/OR-26-683-g004.jpg

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