牙周炎与乳腺癌：一项病例对照研究。

Periodontitis and breast cancer: A case-control study.

作者信息

Sfreddo Camila S, Maier Juliana, De David Silvia C, Susin Cristiano, Moreira Carlos Heitor C

机构信息

Division of Periodontology, Department of Stomatology, Dental School, Federal University of Santa Maria, Santa Maria, RS, Brazil.

Department of Periodontics and Oral Biology, The Dental College of Georgia, Augusta University, Augusta, GA, USA.

出版信息

Community Dent Oral Epidemiol. 2017 Dec;45(6):545-551. doi: 10.1111/cdoe.12318. Epub 2017 Jun 27.

DOI:10.1111/cdoe.12318

PMID:28653758

Abstract

OBJECTIVES

The aim of this case-control study was to evaluate the association between periodontitis and breast cancer in a sample of adult Brazilian women.

METHODS

This was a hospital-based study, which included 67 cases and 134 controls (1:2). Women were selected consecutively between April, 2013 and June, 2015 among those attending the Department of Gynecology at the University Hospital of Santa Maria. Cases were selected among women diagnosed with breast cancer (ICD-10 C50), and controls were matched for age (±2 years), and smoking status (never, former and current smoker). Conditional logistic regression was used to model the association between periodontitis and breast cancer with and without adjustment for potential confounders. Four case definitions for periodontitis were used.

RESULTS

Cases had significantly greater clinical attachment loss than controls (P=.04). After adjusting for important covariates, women diagnosed with periodontitis had two to three times higher odds of breast cancer than women without periodontitis depending on the case definition of periodontitis (P<.05).

CONCLUSIONS

A significant association was observed between periodontitis and breast cancer.

摘要

目的

本病例对照研究旨在评估巴西成年女性样本中牙周炎与乳腺癌之间的关联。

方法

这是一项基于医院的研究，纳入了67例病例和134例对照（1:2）。2013年4月至2015年6月期间，在圣玛丽亚大学医院妇科就诊的女性中连续选取研究对象。病例选自被诊断为乳腺癌（ICD-10 C50）的女性，对照在年龄（±2岁）和吸烟状况（从不吸烟、既往吸烟和当前吸烟）方面进行匹配。使用条件逻辑回归对牙周炎与乳腺癌之间的关联进行建模，同时对潜在混杂因素进行调整和未调整分析。使用了四种牙周炎病例定义。