Yuan Kai, Yu Dahua, Bi Yanzhi, Wang Ruonan, Li Min, Zhang Yajuan, Dong Minghao, Zhai Jinquan, Li Yangding, Lu Xiaoqi, Tian Jie
School of Life Science and Technology, Xidian University, Xi'an, Shaanxi, 710071, People's Republic of China.
Engineering Research Center of Molecular and Neuro Imaging Ministry of Education.
Hum Brain Mapp. 2017 Sep;38(9):4644-4656. doi: 10.1002/hbm.23690. Epub 2017 Jun 27.
Although the activation of the prefrontal cortex (PFC) and the striatum had been found in smoking cue induced craving task, whether and how the functional interactions and white matter integrity between these brain regions contribute to craving processing during smoking cue exposure remains unknown. Twenty-five young male smokers and 26 age- and gender-matched nonsmokers participated in the smoking cue-reactivity task. Craving related brain activation was extracted and psychophysiological interactions (PPI) analysis was used to specify the PFC-efferent pathways contributed to smoking cue-induced craving. Diffusion tensor imaging (DTI) and probabilistic tractography was used to explore whether the fiber connectivity strength facilitated functional coupling of the circuit with the smoking cue-induced craving. The PPI analysis revealed the negative functional coupling of the left dorsolateral prefrontal cortex (DLPFC) and the caudate during smoking cue induced craving task, which positively correlated with the craving score. Neither significant activation nor functional connectivity in smoking cue exposure task was detected in nonsmokers. DTI analyses revealed that fiber tract integrity negatively correlated with functional coupling in the DLPFC-caudate pathway and activation of the caudate induced by smoking cue in smokers. Moreover, the relationship between the fiber connectivity integrity of the left DLPFC-caudate and smoking cue induced caudate activation can be fully mediated by functional coupling strength of this circuit in smokers. The present study highlighted the left DLPFC-caudate pathway in smoking cue-induced craving in smokers, which may reflect top-down prefrontal modulation of striatal reward processing in smoking cue induced craving processing. Hum Brain Mapp 38:4644-4656, 2017. © 2017 Wiley Periodicals, Inc.
尽管在吸烟线索诱发的渴求任务中已发现前额叶皮质（PFC）和纹状体被激活，但在接触吸烟线索期间，这些脑区之间的功能相互作用和白质完整性是否以及如何促成渴求处理仍不清楚。25名年轻男性吸烟者和26名年龄及性别匹配的非吸烟者参与了吸烟线索反应任务。提取与渴求相关的脑激活，并使用心理生理相互作用（PPI）分析来确定对吸烟线索诱发的渴求有贡献的PFC传出通路。采用扩散张量成像（DTI）和概率性纤维束成像来探究纤维连接强度是否促进了该回路与吸烟线索诱发的渴求之间的功能耦合。PPI分析显示，在吸烟线索诱发的渴求任务中，左侧背外侧前额叶皮质（DLPFC）和尾状核之间存在负性功能耦合，这与渴求评分呈正相关。在非吸烟者的吸烟线索暴露任务中未检测到显著激活或功能连接。DTI分析显示，纤维束完整性与吸烟者DLPFC - 尾状核通路中的功能耦合以及吸烟线索诱发的尾状核激活呈负相关。此外，在吸烟者中，左侧DLPFC - 尾状核的纤维连接完整性与吸烟线索诱发的尾状核激活之间的关系可完全由该回路的功能耦合强度介导。本研究强调了吸烟者在吸烟线索诱发的渴求中左侧DLPFC - 尾状核通路，这可能反映了在吸烟线索诱发的渴求处理中前额叶对纹状体奖赏处理的自上而下调节。《人类大脑图谱》38:4644 - 4656，2017年。© 2017威利期刊公司
