Reithofer Manuel, Jahn-Schmid Beatrice
Institute of Pathophysiology and Allergy Research, Medical University of Vienna, Vienna 1090, Austria.
Int J Mol Sci. 2017 Jun 27;18(7):1368. doi: 10.3390/ijms18071368.
Globally, house dust mites (HDM) are one of the main sources of allergens causing Type I allergy, which has a high risk of progressing into a severe disabling disease manifestation such as allergic asthma. The strong protease activities of a number of these allergens are thought to be involved in several steps of the pathophysiology of this allergic disease. It has been a common notion that protease activity may be one of the properties that confers allergenicity to proteins. In this review we summarize and discuss the roles of the different HDM proteases in the development of Type I allergy.
在全球范围内，屋尘螨（HDM）是引发I型过敏的主要过敏原来源之一，I型过敏有很高的风险发展为严重的致残性疾病表现，如过敏性哮喘。这些过敏原中的许多具有强大的蛋白酶活性，被认为参与了这种过敏性疾病病理生理学的多个步骤。人们普遍认为蛋白酶活性可能是赋予蛋白质过敏原性的特性之一。在这篇综述中，我们总结并讨论了不同的屋尘螨蛋白酶在I型过敏发展中的作用。
