Ambulatorio di Allergologia, Clinica San Carlo, Via Ospedale 21, 20037, Paderno Dugnano (MI), Italy.
Department of General Medicine, Immunology and Allergy, IRCCS Foundation Ca' Granda Ospedale Maggiore Policlinico, Via Sforza 35, 20122, Milan, Italy.
Curr Allergy Asthma Rep. 2020 Mar 6;20(4):9. doi: 10.1007/s11882-020-0902-2.
Focusing on the strict relationship between house dust mites and crustaceans from the allergenic point of view.
The well-known tropomyosin was considered for years as the cross-reacting allergen between shrimp and house dust mites. In the last few years, several allergens not only in shrimps but also in house dust mite have been identified and other molecules other than tropomyosin have been shown to cross-react between crustaceans and mites. The present review investigates the very complex allergen sources in shrimp and mites, giving a satisfactorily complete picture of the interrelationships between common allergens. Several minor HDM allergens are homologous to major and minor shrimp allergens; tropomyosin is not the only cross-reactive allergen between shrimp and mites.
从变应原的角度出发，重点关注屋尘螨和甲壳类动物之间的严格关系。
多年来，众所周知的肌球蛋白被认为是虾和屋尘螨之间发生交叉反应的变应原。在过去的几年中，不仅在虾中，而且在屋尘螨中也已经鉴定出了几种过敏原，除了肌球蛋白之外，还发现甲壳类动物和螨之间存在其他发生交叉反应的分子。本综述调查了虾和螨中非常复杂的变应原来源，充分描绘了常见变应原之间的相互关系。一些次要的 HDM 过敏原与主要和次要的虾过敏原同源；肌球蛋白不是虾和螨之间发生交叉反应的唯一变应原。
