Department of Psychology, Center for Lifespan Changes in Brain and Cognition, University of Oslo, Oslo, Norway.
Department of Radiology and Nuclear Medicine, Oslo University Hospital, Oslo, Norway.
Cereb Cortex. 2018 Aug 1;28(8):2775-2785. doi: 10.1093/cercor/bhx157.
Sleep problems relate to brain changes in aging and disease, but the mechanisms are unknown. Studies suggest a relationship between β-amyloid (Aβ) accumulation and sleep, which is likely augmented by interactions with multiple variables. Here, we tested how different cerebrospinal fluid (CSF) biomarkers for brain pathophysiology, brain atrophy, memory function, and depressive symptoms predicted self-reported sleep patterns in 91 cognitively healthy older adults over a 3-year period. The results showed that CSF levels of total- and phosphorylated (P) tau, and YKL-40-a marker of neuroinflammation/astroglial activation-predicted poor sleep in Aβ positive older adults. Interestingly, although brain atrophy was strongly predictive of poor sleep, the relationships between CSF biomarkers and sleep were completely independent of atrophy. A joint analysis showed that unique variance in sleep was explained by P-tau and the P-tau × Aβ interaction, memory function, depressive symptoms, and brain atrophy. The results demonstrate that sleep relates to a range of different pathophysiological processes, underscoring the importance of understanding its impact on neurocognitive changes in aging and people with increased risk of Alzheimer's disease.
睡眠问题与衰老和疾病中的大脑变化有关，但机制尚不清楚。研究表明β-淀粉样蛋白（Aβ）的积累与睡眠之间存在关联，这种关联很可能因与多种变量的相互作用而增强。在这里，我们测试了不同的脑脊液（CSF）生物标志物，包括脑病理生理学、脑萎缩、记忆功能和抑郁症状，这些标志物预测了 91 名认知健康的老年人在 3 年内的自我报告睡眠模式。结果表明，CSF 中总tau 和磷酸化（P）tau 以及 YKL-40（神经炎症/星形胶质细胞激活的标志物）的水平可预测 Aβ阳性老年人的睡眠质量较差。有趣的是，尽管脑萎缩强烈预测睡眠质量较差，但 CSF 生物标志物与睡眠之间的关系与萎缩完全独立。联合分析表明，P-tau 和 P-tau×Aβ 相互作用、记忆功能、抑郁症状和脑萎缩可以解释睡眠的独特差异。研究结果表明，睡眠与一系列不同的病理生理过程有关，这突显了了解睡眠对衰老和阿尔茨海默病风险增加人群的神经认知变化的影响的重要性。
