Pereira Joana B, Westman Eric, Hansson Oskar
Division of Clinical Geriatrics, Department of Neurobiology, Care Sciences and Society, Karolinska Institutet, Stockholm, Sweden.
Division of Clinical Geriatrics, Department of Neurobiology, Care Sciences and Society, Karolinska Institutet, Stockholm, Sweden.
Neurobiol Aging. 2017 Oct;58:14-29. doi: 10.1016/j.neurobiolaging.2017.06.002. Epub 2017 Jun 17.
The aggregation and deposition of amyloid-β (Aβ) peptides into plaques is an early event in Alzheimer's disease (AD), which is followed by different aspects of neurodegeneration that can be measured in the cerebrospinal fluid (CSF) or plasma using neurofilament light (NFL), neurogranin (Ng), total Tau (T-Tau), and phosphorylated tau (P-Tau) levels. The relationship between these biomarkers and regional brain atrophy across the different stages of AD remains largely unexplored. In this study, we assessed whether NFL, Ng, T-Tau, and P-Tau levels in CSF and NFL in plasma are associated with cortical thinning and subcortical volume loss in cognitively normal, mild cognitive impairment, and AD subjects with and without Aβ pathology. Our main findings showed that CSF NFL levels were associated with brain atrophy in all groups, but plasma NFL only correlated with atrophy in symptomatic cases. In contrast, Ng was associated with regional brain atrophy only in individuals with Aβ pathology. Altogether, our main findings suggest that Ng is strongly associated with Aβ pathology, whereas NFL is more unspecific.
淀粉样β（Aβ）肽聚集并沉积形成斑块是阿尔茨海默病（AD）的早期事件，随后会出现神经退行性变的不同方面，可通过使用神经丝轻链（NFL）、神经颗粒素（Ng）、总tau蛋白（T-Tau）和磷酸化tau蛋白（P-Tau）水平在脑脊液（CSF）或血浆中进行检测。这些生物标志物与AD不同阶段全脑萎缩之间的关系在很大程度上仍未得到探索。在本研究中，我们评估了脑脊液中的NFL、Ng、T-Tau和P-Tau水平以及血浆中的NFL水平是否与认知正常、轻度认知障碍以及伴有或不伴有Aβ病理改变的AD受试者的皮质变薄和皮质下体积减少相关。我们的主要研究结果表明，脑脊液NFL水平与所有组的脑萎缩相关，但血浆NFL仅与有症状病例的萎缩相关。相比之下，Ng仅与有Aβ病理改变个体的全脑萎缩相关总的来说，我们的主要研究结果表明，Ng与Aβ病理改变密切相关，而NFL的相关性则更不具有特异性。
