Gontarz M, Wyszyńska-Pawelec G, Zapała J
Department of Cranio-Maxillofacial Surgery, Jagiellonian University Medical College, Rydygier Hospital, Cracow, Poland.
Department of Cranio-Maxillofacial Surgery, Jagiellonian University Medical College, Rydygier Hospital, Cracow, Poland.
Int J Oral Maxillofac Surg. 2018 Jan;47(1):11-15. doi: 10.1016/j.ijom.2017.06.004. Epub 2017 Jun 24.
Primary epithelial tumours of the salivary glands are very rare in paediatric patients. The aim of this study was to evaluate the clinical course, treatment, and outcomes of these uncommon neoplasms based on the authors' experience and the recent literature. The medical charts of 12 female patients and seven male patients with primary epithelial salivary gland tumours were reviewed. All were under 19 years of age and underwent surgical treatment between 1994 and 2016. The results of this group of paediatric patients were compared with those of 621 adult patients. The two most common tumours in the paediatric patients were pleomorphic adenoma and mucoepidermoid carcinoma (89.4%; P=0.004). The incidence of facial nerve palsy following surgery of the parotid tumours was similar in the two groups (P=1.000). The most common primary cancer in the paediatric group was mucoepidermoid carcinoma (77.8%), while in the adult group, adenoid cystic carcinoma was most common (P<0.001). The paediatric group had only low-grade cancers in early stages (P<0.001), with an overall 5-year survival rate of 100%. These results show that the incidence of malignant salivary gland tumours is higher in paediatric patients than in adult patients. This should be taken into account during diagnosis and therapy.
涎腺原发性上皮性肿瘤在儿科患者中非常罕见。本研究的目的是根据作者的经验和近期文献，评估这些罕见肿瘤的临床病程、治疗方法及预后。回顾了12例女性和7例男性原发性涎腺上皮性肿瘤患者的病历。所有患者均未满19岁，于1994年至2016年间接受了手术治疗。将这组儿科患者的结果与621例成年患者的结果进行了比较。儿科患者中最常见的两种肿瘤是多形性腺瘤和黏液表皮样癌（89.4%；P=0.004）。两组腮腺肿瘤手术后面神经麻痹的发生率相似（P=1.000）。儿科组最常见的原发性癌症是黏液表皮样癌（77.8%），而成年组最常见的是腺样囊性癌（P<0.001）。儿科组仅在早期有低级别癌症（P<0.001），总体5年生存率为100%。这些结果表明，儿科患者涎腺恶性肿瘤的发生率高于成年患者。在诊断和治疗过程中应考虑到这一点。
