Ogunmoroti Oluseye, Oni Ebenezer, Michos Erin D, Spatz Erica S, Allen Norrina B, Rana Jamal S, Virani Salim S, Blankstein Ron, Aronis Konstantinos N, Blumenthal Roger S, Veledar Emir, Szklo Moyses, Blaha Michael J, Nasir Khurram
Center for Healthcare Advancement and Outcomes, Baptist Health South Florida, Miami, FL.
Department of Epidemiology, Robert Stempel College of Public Health and Social Work, Florida International University, Miami, FL.
J Am Heart Assoc. 2017 Jun 27;6(6):e005180. doi: 10.1161/JAHA.116.005180.
The American Heart Association introduced the Life's Simple 7 (LS7) metrics to assess and promote cardiovascular health. We sought to examine the association between the LS7 metrics and incident heart failure (HF) in a multiethnic cohort.
We analyzed data from 6506 participants of the Multi-Ethnic Study of Atherosclerosis free of cardiovascular disease at baseline. The LS7 metrics (smoking, physical activity, body mass index, diet, blood pressure, total cholesterol, and blood glucose) were graded on a scale of 0 to 2, with 2 indicating "ideal" status, 1 "intermediate" status, and 0 "poor" status. Points were summed, thus the LS7 score ranged from 0 to 14. Cox proportional hazard ratios and incidence rates of HF per 1000 person-years were calculated. During a median follow-up of 12.2 years, 262 (4%) participants developed HF. Incidence of HF decreased as the number of ideal LS7 metrics increased; 5.9 per 1000 person-years for participants with 0 to 1 ideal metrics and 0.6 per 1000 person-years for those with 6 to 7 ideal metrics. Compared with inadequate scores (0-8 points), hazard ratios for HF were 0.57 (0.43-0.76) and 0.31 (0.19-0.49) for average (9-10 points) and optimal (11-14 points) scores, respectively. A similar pattern was observed when the results were stratified by 4 racial/ethnic groups: white, Chinese American, black, and Hispanic.
A lower risk of HF with more favorable LS7 status regardless of race/ethnicity suggests that efforts to achieve ideal cardiovascular health may reduce the burden of HF, a major source of morbidity and mortality.
美国心脏协会引入了“生命简单7项指标（LS7）”来评估和促进心血管健康。我们试图在一个多民族队列中研究LS7指标与新发心力衰竭（HF）之间的关联。
我们分析了动脉粥样硬化多民族研究中6506名基线时无心血管疾病的参与者的数据。LS7指标（吸烟、身体活动、体重指数、饮食、血压、总胆固醇和血糖）按0至2分级，2表示“理想”状态，1表示“中等”状态，0表示“差”状态。各指标得分相加，因此LS7总分范围为0至14分。计算Cox比例风险比和每1000人年的HF发病率。在中位随访12.2年期间，262名（4%）参与者发生了HF。HF发病率随着理想LS7指标数量的增加而降低；0至1项理想指标的参与者每1000人年为5.9例，6至7项理想指标的参与者每1000人年为0.6例。与得分不足（0 - 8分）相比，平均得分（9 - 10分）和最佳得分（11 - 14分）的HF风险比分别为0.57（0.43 - 0.76）和0.31（0.19 - 0.49）。按4个种族/族裔群体（白人、华裔美国人、黑人、西班牙裔）分层时观察到类似模式。
无论种族/族裔，LS7状态越优，HF风险越低，这表明努力实现理想的心血管健康可能减轻HF负担，HF是发病和死亡的主要原因。
