Liu Yan, Chi Hong-jie, Cui Liu-fu, Yang Xin-chun, Wu Yun-tao, Huang Zhe, Zhao Hai-yan, Gao Jing-sheng, Wu Shou-ling, Cai Jun
Department of Cardiology, Kailuan Hospital, Hebei United University, Tangshan, China.
Department of Cardiology, Chaoyang Hospital, Capital Medical University, Beijing, China.
PLoS One. 2014 Feb 24;9(2):e89161. doi: 10.1371/journal.pone.0089161. eCollection 2014.
BACKGROUND AND AIMS: The American Heart Association has recently established seven ideal cardiovascular health metrics for cardiovascular health promotion and disease reduction (i.e., non-smoking, normal body mass index, physically active, healthy diet, and normal levels of cholesterol, blood pressure and fasting blood glucose). The present study seeks to evaluate how well these metrics predict mortality from all causes and cardiovascular diseases in adult Chinese living in a northern industrial city. METHODS AND RESULTS: Data of 95,429 adults who participated in the Kailuan cohort study from June 2006 to October 2007 was analyzed. All participants underwent questionnaire assessment, clinical examination, laboratory assessments and were followed up biannually. During a median follow-up of 4.02 years, 1,843 deaths occurred, with 597 deaths resulting from cardiovascular diseases. Lower mortality rates from all causes and cardiovascular diseases were observed among the subjects who met a higher number of the ideal health metrics. Compared to the participants who met none or one ideal health metric, those meeting ≥5 ideal health metrics had a lower risk of all-cause mortality by 30% (adjusted hazard ratio, 0.70; 95% confidence interval, 0.56-0.88) and a lower risk of mortality from cardiovascular diseases by 39% (adjusted hazard ratio, 0.61; 95% confidence interval, 0.41-0.89) . Four metrics (smoking status, physical activity, blood pressure and fasting blood glucose) were significantly associated with all-cause mortality. Three metrics (physical activity, blood pressure and fasting blood glucose) were significantly associated with mortality from cardiovascular diseases. CONCLUSION: The number of ideal health metrics is negatively associated with mortality rates from all causes and cardiovascular diseases among adults in a Northern Chinese industrial city. The data supports the AHA recommendation of ideal health metrics for adults from Northern China.
背景与目的:美国心脏协会最近制定了七项理想的心血管健康指标,以促进心血管健康并减少疾病(即不吸烟、正常体重指数、身体活跃、健康饮食以及胆固醇、血压和空腹血糖水平正常)。本研究旨在评估这些指标对居住在北方工业城市的成年中国人全因死亡率和心血管疾病死亡率的预测效果如何。 方法与结果:分析了2006年6月至2007年10月参加开滦队列研究的95429名成年人的数据。所有参与者均接受问卷调查、临床检查、实验室评估,并每半年进行一次随访。在中位随访4.02年期间,共发生1843例死亡,其中597例死于心血管疾病。符合理想健康指标数量较多的受试者全因死亡率和心血管疾病死亡率较低。与未达到或仅达到一项理想健康指标的参与者相比,达到≥5项理想健康指标的参与者全因死亡风险降低30%(调整后危险比,0.70;95%置信区间,0.56 - 0.88),心血管疾病死亡风险降低39%(调整后危险比,0.61;95%置信区间,0.41 - 0.89)。四项指标(吸烟状况、身体活动、血压和空腹血糖)与全因死亡率显著相关。三项指标(身体活动、血压和空腹血糖)与心血管疾病死亡率显著相关。 结论:在中国北方工业城市的成年人中,理想健康指标的数量与全因死亡率和心血管疾病死亡率呈负相关。该数据支持美国心脏协会针对中国北方成年人理想健康指标的建议。
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