失与得的机遇：神经系统发育过程中祖细胞能力的变化
Opportunities lost and gained: Changes in progenitor competence during nervous system development.
作者信息
Farnsworth Dylan R, Doe Chris Q
机构信息
Howard Hughes Medical Institute, University of Oregon, Eugene, OR, USA.
Institute of Molecular Biology, University of Oregon, Eugene, OR, USA.
出版信息
Neurogenesis (Austin). 2017 May 26;4(1):e1324260. doi: 10.1080/23262133.2017.1324260. eCollection 2017.
Abstract
During development of the central nervous system, a small pool of stem cells and progenitors generate the vast neural diversity required for neural circuit formation and behavior. Neural stem and progenitor cells often generate different progeny in response to the same signaling cue (e.g. Notch or Hedgehog), including no response at all. How does stem cell competence to respond to signaling cues change over time? Recently, epigenetics particularly chromatin remodeling - has emerged as a powerful mechanism to control stem cell competence. Here we review recent Drosophila and vertebrate literature describing the effect of epigenetic changes on neural stem cell competence.
摘要
在中枢神经系统发育过程中，一小群干细胞和祖细胞产生了神经回路形成和行为所需的巨大神经多样性。神经干细胞和祖细胞通常会对相同的信号线索（如Notch或Hedgehog）产生不同的子代反应，甚至包括完全无反应。干细胞对信号线索的反应能力是如何随时间变化的呢？最近，表观遗传学，尤其是染色质重塑，已成为控制干细胞反应能力的一种强大机制。在此，我们综述了近期有关果蝇和脊椎动物的文献，这些文献描述了表观遗传变化对神经干细胞反应能力的影响。
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