Central Institute of Mental Health, Department of Psychiatry and Psychotherapy, Medical Faculty Mannheim, University of Heidelberg, Mannheim, Germany.
Department of Psychiatry and Psychotherapy, Charité, Berlin, Germany.
J Sleep Res. 2018 Feb;27(1):73-77. doi: 10.1111/jsr.12577. Epub 2017 Jun 28.
Experimental and clinical evidence suggests an association between neuroplasticity, brain-derived neurotrophic factor and sleep. We aimed at testing the hypotheses that brain-derived neurotrophic factor is associated with specific aspects of sleep architecture or sleep stages in patients with sleep disorders. We included 35 patients with primary insomnia, 31 patients with restless legs syndrome, 17 patients with idiopathic hypersomnia, 10 patients with narcolepsy and 37 healthy controls. Morning serum brain-derived neurotrophic factor concentrations were measured in patients and controls. In patients, blood sampling was followed by polysomnographic sleep investigation. Low brain-derived neurotrophic factor levels were associated with a low percentage of sleep stage N3 and rapid eye movement sleep across diagnostic entities. However, there was no difference in brain-derived neurotrophic factor levels between diagnostic groups. Our data indicate that serum levels of brain-derived neurotrophic factor, independent of a specific sleep disorder, are related to the proportion of sleep stage N3 and REM sleep. This preliminary observation is in accordance with the assumption that sleep stage N3 is involved in the regulation of neuroplasticity.
实验和临床证据表明，神经可塑性、脑源性神经营养因子与睡眠之间存在关联。我们旨在检验以下假设，即脑源性神经营养因子与睡眠障碍患者的睡眠结构或睡眠阶段的特定方面有关。我们纳入了 35 例原发性失眠患者、31 例不安腿综合征患者、17 例特发性嗜睡症患者、10 例发作性睡病患者和 37 例健康对照者。在患者和对照者中均测量了清晨血清脑源性神经营养因子浓度。在患者中，进行了血样采集，随后进行了多导睡眠图睡眠研究。低脑源性神经营养因子水平与所有诊断实体的睡眠阶段 N3 和快速眼动睡眠百分比低有关。然而，不同诊断组之间脑源性神经营养因子水平无差异。我们的数据表明，血清脑源性神经营养因子水平与睡眠阶段 N3 和 REM 睡眠的比例有关，而与特定的睡眠障碍无关。这一初步观察结果与睡眠阶段 N3 参与神经可塑性调节的假设一致。
