School of Dentistry & Oral Health, Griffith University, Southport, QLD, Australia.
Menzies Health Institute Queensland, School of Dentistry & Oral Health, Griffith University, Southport, QLD, Australia.
Oral Dis. 2018 May;24(4):527-536. doi: 10.1111/odi.12708. Epub 2017 Aug 2.
The purpose of this study was to identify the patient populations at risk of medication-related osteonecrosis of the jaw (MRONJ) and determine which medical and dental comorbidities are significant risk factors for this disease. An electronic search of Embase, MEDLINE, Cochrane Central Register of Controlled Trials, WHO International Clinical Trials Registry Platform and ProQuest Dissertations and Theses Global was conducted to identify all human studies that reported risk factors for MRONJ. Only a qualitative analysis was performed due to significant heterogeneity in the collected data. The search strategy identified 2872 records, of which 219 studies were eligible for inclusion. A total of 4106 patients with MRONJ were identified, 39 different systemic diseases were implicated, and 14 medical and 11 dental risk factors were reported, although no statistical analysis of the significance of each of these factors was possible. The clinical reach of MRONJ may be wider than anticipated, and more data on the significance of each potential risk factor are needed to guide the identification and management of at-risk patients.
本研究旨在确定易发生药物相关性颌骨坏死（MRONJ）的患者人群，并确定哪些医学和牙科合并症是该疾病的重要危险因素。通过对 Embase、MEDLINE、Cochrane 中央对照试验注册库、世界卫生组织国际临床试验注册平台和 ProQuest Dissertations and Theses Global 进行电子检索，确定了所有报告 MRONJ 危险因素的人类研究。由于收集的数据存在显著异质性，因此仅进行了定性分析。搜索策略确定了 2872 条记录，其中 219 项研究符合纳入标准。共确定了 4106 例 MRONJ 患者，涉及 39 种不同的系统性疾病，并报告了 14 种医学和 11 种牙科危险因素，但由于无法对这些因素中的每一个进行统计学意义分析，因此无法确定这些因素的临床意义。MRONJ 的临床影响可能比预期的更广泛，需要更多关于每个潜在危险因素的重要性的数据，以指导对高危患者的识别和管理。
