Department of Epidemiology and Preventive Medicine, Ehime University Graduate School of Medicine, Ehime, Japan.
Epidemiology and Medical Statistics Unit, Translational Research Center, Ehime University Hospital, Ehime, Japan.
Geriatr Gerontol Int. 2017 Dec;17(12):2460-2465. doi: 10.1111/ggi.13103. Epub 2017 Jun 28.
Nocturia is common among patients with type 2 diabetes mellitus, but limited evidence regarding the association between body mass index (BMI) and nocturia exists among such patients. The aim of the present study, therefore, was to evaluate the association between BMI and nocturia among Japanese patients with type 2 diabetes mellitus.
Study participants were 809 Japanese patients with type 2 diabetes mellitus. Study participants were considered to have nocturia if they answered "two or more" to the question: "How many times do you typically wake up to urinate from sleeping at night until waking in the morning?" We used the following two outcomes: (i) moderate nocturia was defined as ≥2 voids per night; and (ii) severe nocturia was defined as ≥3 voids per night. Participants were categorized into four groups according to their BMI: (i) BMI <18.5; (ii) 18.5 ≤ BMI < 25; (iii) 25 ≤ BMI < 30; and (iv) BMI ≥30. Multiple logistical regression analysis for nocturia in relation to BMI was used, with the category of 18.5 ≤ BMI < 25 as the reference.
Obesity (BMI ≥30) was independently positively associated with severe nocturia among elderly patients (age ≥65 years) with type 2 diabetes mellitus, but not among young and middle-aged patients: the adjusted OR was 2.96 (95% CI 1.10-7.83). BMI was not associated with moderate nocturia in all patients.
In Japanese elderly patients with type 2 diabetes mellitus, obesity was independently positively associated with severe nocturia. Geriatr Gerontol Int 2017; 17: 2460-2465.
夜尿症在 2 型糖尿病患者中较为常见，但关于此类患者的体重指数（BMI）与夜尿症之间的关联，现有证据有限。因此，本研究旨在评估日本 2 型糖尿病患者的 BMI 与夜尿症之间的关系。
研究参与者为 809 名日本 2 型糖尿病患者。如果研究参与者对以下问题回答“两次或两次以上”，则认为他们患有夜尿症：“从晚上入睡到早上醒来，您通常要醒来多少次去排尿？”我们使用以下两个结果：（i）中度夜尿症定义为每晚≥2 次排尿；（ii）重度夜尿症定义为每晚≥3 次排尿。根据 BMI 将参与者分为四组：（i）BMI<18.5；（ii）18.5≤BMI<25；（iii）25≤BMI<30；（iv）BMI≥30。使用多变量逻辑回归分析 BMI 与夜尿症的关系，以 BMI 为 18.5≤BMI<25 的组为参考。
在患有 2 型糖尿病的老年（年龄≥65 岁）患者中，肥胖（BMI≥30）与重度夜尿症独立正相关，但在年轻和中年患者中并非如此：调整后的 OR 值为 2.96（95%CI 1.10-7.83）。在所有患者中，BMI 与中度夜尿症无关。
在日本患有 2 型糖尿病的老年患者中，肥胖与重度夜尿症独立正相关。老年医学与老年病学杂志 2017；17：2460-2465。
