Department of Urology, Mayo Clinic, Rochester, MN 55905, USA.
BJU Int. 2012 Sep;110(6):848-53. doi: 10.1111/j.1464-410X.2011.10806.x. Epub 2012 Jan 10.
What's known on the subject? and What does the study add? Nocturia has been associated with multiple chronic conditions, however, previous studies have been conducted only at a single time. We found that nocturia preceded the development CHD in young men. Moderate nocturia may be an early marker of CHD in young men.
To determine whether nocturia is associated with the development of diabetes mellitus, hypertension, coronary heart disease (CHD) and occurrence of death.
We studied data obtained from a retrospective cohort of randomly selected men, aged 40-79 years in 1990, from Olmsted County, MN, USA. Moderate nocturia was defined as waking to urinate ≥2 times per night. Men were followed every 2 years through repeated questionnaires and community medical records to assess development of diabetes mellitus and hypertension, and occurrence of death. CHD was ascertained through ongoing surveillance of heart disease in Olmsted County. Cox proportional hazard models were used to estimate associations between baseline nocturia and each of the outcomes.
A total of 2447 men were followed for a median of 17.1 years (25th and 75th percentiles: 15.0, 17.4 years). Moderate nocturia was not significantly associated with the later development of diabetes mellitus or hypertension in this study. Younger men (<60 years of age) with moderate nocturia were more likely to develop CHD later in life than younger men without nocturia (hazard ratio [HR]: 1.68; 95% confidence interval [CI]: 1.13, 2.49). This association was no longer significant when adjusted for age, body mass index (BMI) and urological medications (HR: 1.36; 95% CI: 0.87, 2.12). Older men (≥60 years of age) with moderate nocturia were more likely to die than older men without moderate nocturia, even after adjusting for age, BMI, urological medications and CHD (HR: 1.48; 95% CI: 1.15, 1.91).
Nocturia may be a marker for increased risk of CHD in younger men, and death in older men.
目的：确定夜尿症是否与糖尿病、高血压、冠心病（CHD）的发展和死亡的发生有关。
材料和方法：我们研究了来自美国明尼苏达州奥姆斯特德县的一个随机选择的 40-79 岁男性的回顾性队列的数据。中度夜尿症定义为每晚醒来排尿≥2 次。通过反复的问卷调查和社区医疗记录，对男性进行随访，以评估糖尿病和高血压的发生情况，以及死亡情况。通过奥姆斯特德县心脏病的持续监测来确定 CHD。使用 Cox 比例风险模型来估计基线夜尿症与每种结局之间的关联。
结果：共有 2447 名男性被随访，中位随访时间为 17.1 年（25%和 75%分位数：15.0、17.4 年）。在这项研究中，中度夜尿症与后来发生糖尿病或高血压没有显著相关性。患有中度夜尿症的年轻男性（<60 岁）比没有夜尿症的年轻男性更有可能在以后的生活中患上 CHD（风险比[HR]：1.68；95%置信区间[CI]：1.13，2.49）。当调整年龄、体重指数（BMI）和泌尿科药物时，这种相关性不再显著（HR：1.36；95%CI：0.87，2.12）。患有中度夜尿症的老年男性（≥60 岁）比没有中度夜尿症的老年男性更有可能死亡，即使在调整了年龄、BMI、泌尿科药物和 CHD 后也是如此（HR：1.48；95%CI：1.15，1.91）。
结论：夜尿症可能是年轻男性 CHD 风险增加的标志物，也是老年男性死亡的标志物。
