Watanabe Yuki, Osawa Kayo, Sato Itsuko, Iwatani Sota, Kono Ruri, Hayakawa Ikuyo, Hayashi Nobuhide, Iijima Kazumoto, Saegusa Jun, Morioka Ichiro
1 Department of Clinical Laboratory, Kobe University Hospital, Kobe, Japan.
2 Infection Control and Prevention, Kobe University Hospital, Kobe, Japan.
Ann Clin Biochem. 2018 May;55(3):400-403. doi: 10.1177/0004563217721253. Epub 2017 Jul 20.
Background Our aim was to determine whether the postnatal age or postmenstrual age is a more appropriate criterion for evaluating foetal haemoglobin concentrations. Methods Blood samples ( n = 1095) were obtained from 394 infants and were divided into two groups based on gestational age at birth: <37 weeks ( n = 491) and ≥37 weeks ( n = 604). (1) Foetal haemoglobin concentrations divided by one month at age after birth were compared between the groups. (2) Foetal haemoglobin concentrations divided into ≤9 months from last menstruation and one month thereafter were compared between the groups. Results In samples from infants ≥37 weeks' gestational age at birth, the median foetal haemoglobin concentrations were 69.5%, 21.4% and 3.6% at 0-1 month, 2-3 months and ≥5 months after birth, respectively. The median foetal haemoglobin concentrations in infants <37 weeks' gestational age at birth were 75.5%, 62.7% and 5.1% at 0-1 month, 2-3 months and ≥5 months after birth, respectively. The median foetal haemoglobin concentrations in infants <37 weeks' gestational age at birth were significantly higher than that in infants ≥37 weeks' gestational age at birth at all postnatal age points. (2) There was no significant difference between the groups at all age points after nine months of postmenstrual age: 72.5 and 75.3% at 9-10 months, 25.1 and 26.6% at 11-12 months and 5.5 and 4.6% at >13 months after last menstruation in infants ≥37 and <37 weeks' gestational age at birth, respectively. Conclusions Evaluation of foetal haemoglobin concentrations at postmenstrual age is unaffected by gestational age at birth.
背景 我们的目的是确定出生后年龄或月经后年龄是否是评估胎儿血红蛋白浓度更合适的标准。方法 从394名婴儿中采集血样（n = 1095），并根据出生时的胎龄分为两组：<37周（n = 491）和≥37周（n = 604）。（1）比较两组出生后按年龄每1个月划分的胎儿血红蛋白浓度。（2）比较两组按末次月经后≤9个月及之后每1个月划分的胎儿血红蛋白浓度。结果 在出生时胎龄≥37周的婴儿样本中，出生后0 - 1个月、2 - 3个月和≥5个月时胎儿血红蛋白浓度的中位数分别为69.5%、21.4%和3.6%。出生时胎龄<37周的婴儿在出生后0 - 1个月、2 - 3个月和≥5个月时胎儿血红蛋白浓度的中位数分别为75.5%、62.7%和5.1%。出生时胎龄<37周的婴儿在所有出生后年龄点的胎儿血红蛋白浓度中位数均显著高于出生时胎龄≥37周的婴儿。（2）月经后年龄9个月后的所有年龄点两组之间无显著差异：出生时胎龄≥37周和<37周的婴儿在末次月经后9 - 10个月时分别为72.5%和75.3%，11 - 12个月时分别为25.1%和26.6%，>13个月时分别为5.5%和4.6%。结论 月经后年龄时胎儿血红蛋白浓度的评估不受出生时胎龄的影响。
