Henry Audrey, Tourbah Ayman, Chaunu Marie-Pierre, Bakchine Serge, Montreuil Michèle
1Cognition,Health and Socialization lab,University of Reims Champagne-Ardenne,Reims,France.
2Psychopathology and Neuropsychology lab,University of Paris 8,Saint-Denis,France.
J Int Neuropsychol Soc. 2017 Sep;23(8):653-664. doi: 10.1017/S1355617717000510. Epub 2017 Jun 28.
Multiple sclerosis (MS) can be associated with impaired social cognition. However, social cognition skills have never been explored in the different subtypes of MS. The first aim of this study was to examine whether MS subtypes differ on the course of social cognition. The second aim was to explore the relationship between social cognition performances and executive abilities and mood variables.
Sixty-two patients with MS and 33 healthy matched controls performed experimental tasks assessing facial emotion recognition, theory of mind (ToM), and cognitive functioning, in particular executive functions.
Patients differed from controls on both measures of social cognition. On the ToM measures, patients with progressive MS scored significantly lower than healthy participants. Patients with primary progressive MS performed worse than both healthy participants and patients with relapsing-remitting MS on the recognition of fearful facial expressions, while patients with secondary progressive MS performed worse on the recognition of facial expressions of sadness. Patients' social cognition difficulties were correlated with processing speed, working memory, and verbal fluency.
These preliminary results suggested that there may be qualitative differences in social cognition difficulties among the phenotypes. Furthermore, these impairments were related to executive functions, but unrelated to patients' disability or level of depression. These data highlight the need for research to determine the real impact of these deficits on interpersonal relationships among patients and to confirm these disorders in a larger population with progressive forms of MS. (JINS, 2017, 23, 653-664).
多发性硬化症（MS）可能与社会认知受损有关。然而，从未在MS的不同亚型中探究过社会认知技能。本研究的首要目的是检验MS各亚型在社会认知过程中是否存在差异。第二个目的是探究社会认知表现与执行能力及情绪变量之间的关系。
62例MS患者和33例健康对照者完成了评估面部情绪识别、心理理论（ToM）和认知功能（特别是执行功能）的实验任务。
患者在社会认知的两项测量指标上均与对照组存在差异。在ToM测量中，进展型MS患者的得分显著低于健康参与者。原发性进展型MS患者在恐惧面部表情识别方面的表现比健康参与者和复发缓解型MS患者都差，而继发性进展型MS患者在悲伤面部表情识别方面表现更差。患者的社会认知困难与处理速度、工作记忆和语言流畅性相关。
这些初步结果表明，各表型在社会认知困难方面可能存在质的差异。此外，这些损害与执行功能有关，但与患者的残疾程度或抑郁水平无关。这些数据凸显了开展研究以确定这些缺陷对患者人际关系的实际影响，并在更大规模的进展型MS患者群体中证实这些障碍的必要性。（《神经心理疾病与认知障碍杂志》，2017年，第23卷，第653 - 664页）
