Doskas Triantafyllos K, Christidi Foteini, Spiliopoulos Kanellos C, Tsiptsios Dimitrios, Vavougios George D, Tsiakiri Anna, Vorvolakos Theofanis, Kokkotis Christos, Iliopoulos Ioannis, Aggelousis Nikolaos, Vadikolias Konstantinos
Neurology Department, Athens Naval Hospital, 11521 Athens, Greece.
Neurology Department, Democritus University of Thrace, 68100 Alexandroupolis, Greece.
Neurol Int. 2023 Sep 1;15(3):1106-1116. doi: 10.3390/neurolint15030068.
Multiple sclerosis (MS) is a chronic immune-mediated disease of the central nervous system (CNS), characterized by the diffuse grey and white matter damage. Cognitive impairment (CI) is a frequent clinical feature in patients with MS (PwMS) that can be prevalent even in early disease stages, affecting the physical activity and active social participation of PwMS. Limited information is available regarding the influence of MS in social cognition (SC), which may occur independently from the overall neurocognitive dysfunction. In addition, the available information regarding the factors that influence SC in PwMS is limited, e.g., factors such as a patient's physical disability, different cognitive phenotypes, mood status, fatigue. Considering that SC is an important domain of CI in MS and may contribute to subjects' social participation and quality of life, we herein conceptualize and present the methodological design of a cross-sectional study in 100 PwMS of different disease subtypes. The study aims (a) to characterize SC impairment in PwMS in the Greek population and (b) to unveil the relationship between clinical symptoms, phenotypes of CI, mood status and fatigue in PwMS and the potential underlying impairment on tasks of SC.
多发性硬化症（MS）是一种中枢神经系统（CNS）的慢性免疫介导疾病，其特征是弥漫性灰质和白质损伤。认知障碍（CI）是MS患者（PwMS）常见的临床特征，甚至在疾病早期阶段就可能普遍存在，影响PwMS的身体活动和积极的社会参与。关于MS对社会认知（SC）的影响的信息有限，SC可能独立于整体神经认知功能障碍而发生。此外，关于影响PwMS中SC的因素的现有信息有限，例如患者的身体残疾、不同的认知表型、情绪状态、疲劳等因素。鉴于SC是MS中CI的一个重要领域，可能有助于受试者的社会参与和生活质量，我们在此概念化并展示了一项针对100名不同疾病亚型PwMS的横断面研究的方法设计。该研究旨在（a）描述希腊人群中PwMS的SC损伤情况，以及（b）揭示PwMS的临床症状、CI表型、情绪状态和疲劳与SC任务潜在的潜在损伤之间的关系。
