Yamauchi Yoko, Nagatoya Katsuyuki, Okuno Ayako, Fujii Naohiko, Inoue Toru
Department of Nephrology, Hyogo Prefectural Nishinomiya Hospital, Hyogo, Japan.
Department of Nephrology, Osaka Medical College, Osaka, Japan.
NDT Plus. 2010 Jun;3(3):279-281. doi: 10.1093/ndtplus/sfq013. Epub 2010 Feb 28.
Thrombotic thrombocytopenic purpura (TTP) complicated with myeloperoxidase anti-neutrophil cytoplasmic autoantibody (MPO-ANCA)-associated vasculitis is rare and generally has a serious prognosis. We report a case wherein TTP was successfully treated with repeated plasma exchange (PE) and MPO-ANCA-associated vasculitis with corticosteroids. The renal function consequently improved such that haemodialysis could be discontinued and the patient was discharged without any significant complications.
血栓性血小板减少性紫癜(TTP)合并髓过氧化物酶抗中性粒细胞胞浆自身抗体(MPO-ANCA)相关血管炎较为罕见,且通常预后严重。我们报告一例TTP患者经反复血浆置换(PE)成功治疗,MPO-ANCA相关血管炎经皮质类固醇治疗。肾功能因此得到改善,以至于可以停止血液透析,患者出院时无任何严重并发症。